Beta-arrestin-1 - TAS2R9 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R9 75.5
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 233 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 233 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 230 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 230 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 111 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 111 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 N 113 34x44 s15s16 T 246 C.s15s16.05
Hydrophobic TM4 I 126 4x38 s8s9 T 136 N.s8s9.07
Polar H8 S 287 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 287 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 287 8x48 s5s6 D 69 N.s5s6.06
Polar TM7 G 285 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM7 G 285 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 G 285 7x56 s5s6 G 72 N.s5s6.09
Polar TM6 D 221 6x25 S6 D 78 N.S6.04
Hydrophobic TM6 D 221 6x25 S6 D 78 N.S6.04
Hydrophobic TM5 L 201 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 I 44 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 205 5x65 s5s6 L 73 N.s5s6.10
Polar ICL2 K 123 34x54 s8s9 T 136 N.s8s9.07
Polar TM6 S 223 6x27 S6 R 76 N.S6.02
Hydrophobic TM6 S 223 6x27 S6 R 76 N.S6.02
Van-der-waals TM6 S 223 6x27 S6 R 76 N.S6.02
Hydrophobic TM6 A 230 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 230 6x34 s5s6 L 71 N.s5s6.08
Polar TM3 Y 107 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 107 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 107 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 F 106 3x49 s5s6 V 70 N.s5s6.07
Ionic TM1 R 38 1x64 s5s6 E 66 N.s5s6.03
Polar TM1 R 38 1x64 s5s6 E 66 N.s5s6.03
Van-der-waals TM1 R 38 1x64 s5s6 E 66 N.s5s6.03
Polar ICL2 N 113 34x44 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 N 113 34x44 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 N 113 34x44 s15s16 F 244 C.s15s16.03
Polar H8 N 286 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 286 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 286 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 111 3x54 s5s6 L 71 N.s5s6.08
Aromatic TM5 H 208 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 H 208 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 H 208 5x68 S6 F 75 N.S6.01
Hydrophobic TM3 Y 107 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 V 234 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 234 6x38 s5s6 L 71 N.s5s6.08
Polar ICL2 K 123 34x54 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 K 123 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 123 34x54 s15s16 N 245 C.s15s16.04
Ionic ICL3 R 220 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 220 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 R 220 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 220 - s9s10 E 155 N.s9s10.07
Polar TM3 I 111 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 111 3x54 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 I 111 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 113 34x44 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 N 113 34x44 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 F 106 3x49 s5s6 D 67 N.s5s6.04
Aromatic TM5 H 208 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 208 5x68 s15s16 F 244 C.s15s16.03
Polar H8 K 288 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 288 8x49 s5s6 D 69 N.s5s6.06
Polar TM3 K 110 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 K 110 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 K 110 3x53 s5s6 R 65 N.s5s6.02
Aromatic TM6 H 227 6x31 S6 F 75 N.S6.01
Hydrophobic TM6 H 227 6x31 S6 F 75 N.S6.01
Van-der-waals TM6 H 227 6x31 S6 F 75 N.S6.01
Ionic TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 111 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 111 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 H 227 6x31 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 227 6x31 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 226 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 226 6x30 s5s6 L 73 N.s5s6.10
Polar TM7 G 285 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 G 285 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 G 285 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 111 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 111 3x54 s5s6 V 70 N.s5s6.07
Polar TM3 K 110 3x53 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 124 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 124 34x55 s8s9 T 136 N.s8s9.07