Beta-arrestin-2 - TP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TP 81.5
Beta-arrestin-2 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 140 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 140 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL1 H 58 - s5s6 D 70 N.s5s6.06
Van-der-waals ICL1 H 58 - s5s6 D 70 N.s5s6.06
Hydrophobic C-term L 332 - S6 T 84 N.S6.09
Hydrophobic TM3 R 130 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 130 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 243 6x33 s5s6 S 75 N.s5s6.11
Polar TM2 S 62 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 62 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 F 63 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 F 63 2x39 s5s6 L 72 N.s5s6.08
Polar TM4 S 145 4x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 134 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 134 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 M 243 6x33 S6 F 76 N.S6.01
Hydrophobic TM2 F 63 2x39 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 E 240 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 E 240 6x30 s15s16 F 245 C.s15s16.03
Aromatic ICL2 F 138 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 138 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 138 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 P 137 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic H8 P 327 8x62 s9s10 E 156 N.s9s10.07
Van-der-waals H8 P 327 8x62 s9s10 E 156 N.s9s10.07
Hydrophobic TM5 L 222 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 222 5x65 S6 F 76 N.S6.01
Polar H8 R 312 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic H8 R 312 8x47 s5s6 L 72 N.s5s6.08
Van-der-waals H8 R 312 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 A 231 - S6 K 78 N.S6.03
Van-der-waals ICL3 A 231 - S6 K 78 N.S6.03
Polar ICL2 P 137 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 138 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 F 138 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 M 243 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 M 243 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 L 64 2x40 s5s6 L 72 N.s5s6.08
Polar H8 R 312 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 R 312 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 312 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 G 133 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 133 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 L 64 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 64 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 225 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 225 5x68 s15s16 F 245 C.s15s16.03
Polar ICL2 A 144 34x57 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 R 235 6x25 S5 A 61 N.S5.09
Van-der-waals TM6 R 235 6x25 S5 A 61 N.S5.09
Hydrophobic TM3 E 129 3x49 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 E 129 3x49 s5s6 L 69 N.s5s6.05
Polar ICL2 A 142 34x55 s8s9 E 135 N.s8s9.05
Polar TM2 S 61 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 61 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 61 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 M 243 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 M 243 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 H 58 - s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 H 58 - s5s6 V 71 N.s5s6.07
Polar TM6 Q 234 6x24 S6 L 80 N.S6.05
Hydrophobic TM6 Q 234 6x24 S6 L 80 N.S6.05
Van-der-waals TM6 Q 234 6x24 S6 L 80 N.S6.05
Hydrophobic ICL2 P 141 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 141 34x54 s8s9 D 136 N.s8s9.06
Ionic TM3 E 129 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 E 129 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 E 129 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 S 61 2x37 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 138 34x51 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 F 138 34x51 s8s9 A 140 N.s8s9.10
Hydrophobic ICL2 P 137 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 64 N.S5.12
Polar ICL2 V 143 34x56 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 V 143 34x56 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 V 143 34x56 s8s9 E 135 N.s8s9.05
Polar ICL3 E 230 - s17s18 N 312 C.s17s18.37
Hydrophobic ICL3 E 230 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 E 230 - s17s18 N 312 C.s17s18.37
Hydrophobic ICL2 P 141 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 P 141 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic TM6 Q 234 6x24 S6 D 79 N.S6.04
Van-der-waals TM6 Q 234 6x24 S6 D 79 N.S6.04
Polar ICL1 H 58 - s5s6 E 67 N.s5s6.03
Polar TM6 R 235 6x25 S5 F 62 N.S5.10
Van-der-waals TM6 R 235 6x25 S5 F 62 N.S5.10
Polar TM3 I 134 3x54 S5 Y 64 N.S5.12
Hydrophobic TM3 I 134 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 I 134 3x54 S5 Y 64 N.S5.12
Polar TM6 R 235 6x25 S6 R 77 N.S6.02
Hydrophobic TM6 R 235 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 R 235 6x25 S6 R 77 N.S6.02
Polar TM6 R 235 6x25 S6 K 78 N.S6.03
Hydrophobic TM6 R 235 6x25 S6 K 78 N.S6.03
Van-der-waals TM6 R 235 6x25 S6 K 78 N.S6.03
Ionic ICL1 R 60 - s20c D 402 C.s20c.12
Polar ICL1 R 60 - s20c D 402 C.s20c.12
Hydrophobic ICL1 R 60 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 60 - s20c D 402 C.s20c.12
Polar H8 R 317 8x52 s9s10 K 158 N.s9s10.09
Hydrophobic H8 R 317 8x52 s9s10 K 158 N.s9s10.09
Van-der-waals H8 R 317 8x52 s9s10 K 158 N.s9s10.09
Hydrophobic TM2 L 67 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 F 138 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 F 138 34x51 S8 L 130 N.S8.03
Hydrophobic TM6 P 236 6x26 S6 I 82 N.S6.07
Hydrophobic ICL2 P 141 34x54 s8s9 E 135 N.s8s9.05
Ionic TM6 R 235 6x25 S6 D 79 N.S6.04
Polar TM6 R 235 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 R 235 6x25 S6 D 79 N.S6.04
Van-der-waals TM6 R 235 6x25 S6 D 79 N.S6.04
Hydrophobic ICL2 F 138 34x51 s8s9 P 132 N.s8s9.02
Polar ICL2 A 142 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 A 142 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 A 142 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 E 230 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 E 230 - s17s18 V 315 C.s17s18.40