Beta-arrestin-1 - TA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TA1 85.9
Beta-arrestin-1 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 Y 308 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic C-term F 334 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term F 334 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 P 128 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 Q 220 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 220 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 A 124 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 124 3x53 s5s6 L 68 N.s5s6.05
Polar C-term S 338 - S10 R 165 N.S10.03
Van-der-waals C-term S 338 - S10 R 165 N.S10.03
Hydrophobic TM3 A 124 3x53 s5s6 V 70 N.s5s6.07
Polar TM6 K 245 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 K 245 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 245 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 A 249 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 249 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 249 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 249 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 N 228 5x76 S6 D 78 N.S6.04
Polar ICL2 K 132 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 K 132 34x54 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 K 132 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic H8 W 310 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 W 310 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 W 310 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 I 224 5x72 S6 K 77 N.S6.03
Hydrophobic ICL3 M 237 - s9s10 L 154 N.s9s10.03
Polar C-term S 339 - s20c E 404 C.s20c.14
Polar TM3 C 126 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 126 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 P 128 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 V 256 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 256 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 128 34x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 129 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 129 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 128 34x50 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 P 128 34x50 s5s6 G 64 N.s5s6.01
Polar H8 Y 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 Y 308 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Y 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 129 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 129 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 I 224 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 Y 131 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 131 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 K 248 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 I 213 5x61 s5s6 L 73 N.s5s6.10
Polar C-term L 337 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term L 337 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 L 129 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 129 34x51 S8 L 129 N.S8.03
Polar TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Polar ICL2 R 130 34x52 S16 Q 248 C.S16.02
Hydrophobic TM5 A 227 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 A 227 5x75 S6 K 77 N.S6.03
Hydrophobic TM5 Q 220 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 220 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 L 231 5x79 S6 L 79 N.S6.05
Van-der-waals TM5 L 231 5x79 S6 L 79 N.S6.05
Hydrophobic TM3 V 125 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 V 125 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 K 132 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 132 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 L 253 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 253 6x37 s5s6 L 71 N.s5s6.08
Polar C-term E 336 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term E 336 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term L 337 - S10 R 165 N.S10.03
Van-der-waals C-term L 337 - S10 R 165 N.S10.03
Ionic ICL2 K 132 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 K 132 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 K 132 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 V 125 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 V 125 3x54 s5s6 V 70 N.s5s6.07
Polar ICL2 R 130 34x52 S16 Y 249 C.S16.03
Aromatic ICL2 R 130 34x52 S16 Y 249 C.S16.03
Hydrophobic C-term K 332 - s20c E 404 C.s20c.14
Van-der-waals C-term K 332 - s20c E 404 C.s20c.14
Polar TM5 L 223 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 L 223 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 L 223 5x71 S6 K 77 N.S6.03
Polar C-term K 332 - s20c K 403 C.s20c.13
Hydrophobic C-term K 332 - s20c K 403 C.s20c.13
Van-der-waals C-term K 332 - s20c K 403 C.s20c.13
Hydrophobic TM5 A 217 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 217 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Y 131 34x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 Y 210 5x58 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 Y 210 5x58 s5s6 L 71 N.s5s6.08
Polar C-term L 337 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term L 337 - s5s6 E 66 N.s5s6.03
Van-der-waals C-term L 337 - s5s6 E 66 N.s5s6.03
Polar ICL2 K 132 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 132 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 I 213 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 121 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 129 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 129 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL3 M 237 - S6 N 83 N.S6.09
Van-der-waals ICL3 M 237 - S6 N 83 N.S6.09
Hydrophobic TM5 L 231 5x79 s7s8 L 123 N.s7s8.06
Hydrophobic TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 337 - S5 R 62 N.S5.11
Van-der-waals C-term L 337 - S5 R 62 N.S5.11
Hydrophobic ICL2 L 129 34x51 S9 C 140 N.S9.01
Hydrophobic ICL3 L 235 - S6 F 80 N.S6.06
Van-der-waals ICL3 L 235 - S6 F 80 N.S6.06
Hydrophobic TM5 I 224 5x72 S6 R 76 N.S6.02
Ionic TM6 K 248 6x32 s5s6 D 69 N.s5s6.06
Polar C-term S 339 - S1 K 11 N.S1.04
Van-der-waals C-term S 339 - S1 K 11 N.S1.04