Beta-arrestin-2 - TAAR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAAR2 81.6
Beta-arrestin-2 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 243 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 243 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 246 - S6 L 80 N.S6.05
Van-der-waals ICL3 L 246 - S6 L 80 N.S6.05
Hydrophobic TM5 S 236 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 S 236 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 263 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 264 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 149 34x51 S9 C 141 N.S9.01
Polar TM5 A 242 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 A 242 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 A 242 5x71 S6 K 78 N.S6.03
Polar ICL2 Y 151 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 151 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 151 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 A 260 6x33 s5s6 G 73 N.s5s6.09
Polar C-term S 350 - S10 R 166 N.S10.03
Van-der-waals C-term S 350 - S10 R 166 N.S10.03
Hydrophobic ICL2 L 149 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 149 34x51 S16 A 248 C.S16.01
Hydrophobic ICL3 L 246 - S6 D 79 N.S6.04
Van-der-waals ICL3 L 246 - S6 D 79 N.S6.04
Hydrophobic TM7 F 318 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 F 318 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 144 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 144 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 246 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 246 - S6 K 78 N.S6.03
Hydrophobic TM3 I 145 3x54 S6 F 76 N.S6.01
Polar TM5 H 239 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 239 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 239 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 239 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic H8 P 320 8x48 s5s6 V 71 N.s5s6.07
Van-der-waals H8 P 320 8x48 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 149 34x51 S8 L 130 N.S8.03
Hydrophobic TM3 I 145 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 145 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 145 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 I 232 5x61 s5s6 L 74 N.s5s6.10
Polar C-term Q 347 - s5s6 E 67 N.s5s6.03
Hydrophobic C-term Q 347 - s5s6 E 67 N.s5s6.03
Van-der-waals C-term Q 347 - s5s6 E 67 N.s5s6.03
Hydrophobic TM5 I 243 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 I 243 5x72 S6 R 77 N.S6.02
Ionic C-term K 348 - s5s6 D 70 N.s5s6.06
Polar C-term K 348 - s5s6 D 70 N.s5s6.06
Van-der-waals C-term K 348 - s5s6 D 70 N.s5s6.06
Hydrophobic TM6 K 259 6x32 s5s6 G 73 N.s5s6.09
Polar TM6 K 256 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 256 6x29 s5s6 S 75 N.s5s6.11
Ionic C-term E 349 - s9s10 K 161 N.s9s10.12
Polar C-term E 349 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 349 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 349 - s9s10 K 161 N.s9s10.12
Van-der-waals H8 Y 319 8x47 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 145 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 145 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 L 149 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 149 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 149 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 148 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 148 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 148 34x50 S5 Y 64 N.S5.12
Polar ICL2 S 152 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 S 152 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 S 152 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 I 243 5x72 S6 K 78 N.S6.03
Hydrophobic TM6 A 260 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 260 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term I 343 - s20c Y 404 C.s20c.14
Van-der-waals C-term I 343 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 149 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 149 34x51 S15 I 242 C.S15.14
Polar C-term N 341 - s20c Y 404 C.s20c.14
Hydrophobic C-term N 341 - s20c Y 404 C.s20c.14
Van-der-waals C-term N 341 - s20c Y 404 C.s20c.14
Polar ICL2 S 152 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic H8 Y 319 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Y 319 8x47 s5s6 V 71 N.s5s6.07
Polar C-term Q 347 - s8s9 K 139 N.s8s9.09
Hydrophobic C-term Q 347 - s8s9 K 139 N.s8s9.09
Van-der-waals C-term Q 347 - s8s9 K 139 N.s8s9.09
Polar C-term S 350 - S9 R 148 N.S9.08
Van-der-waals C-term S 350 - S9 R 148 N.S9.08
Ionic C-term E 351 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term E 351 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term E 351 - s9s10 K 158 N.s9s10.09
Hydrophobic TM5 A 242 5x71 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 239 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 H 239 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 H 239 5x68 S6 F 76 N.S6.01
Polar ICL2 L 149 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 149 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 149 34x51 S16 Y 250 C.S16.03