Beta-arrestin-2 - TAAR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
TAAR3 78.2
Beta-arrestin-2 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM5 I 231 5x72 s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 L 137 34x51 S9 C 141 N.S9.01
Hydrophobic TM5 V 230 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 230 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 P 136 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic C-term F 339 - s5s6 E 67 N.s5s6.03
Van-der-waals C-term F 339 - s5s6 E 67 N.s5s6.03
Polar ICL2 Y 139 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 139 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 139 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 137 34x51 S8 L 130 N.S8.03
Hydrophobic ICL2 P 136 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 136 34x50 S5 Y 64 N.S5.12
Polar TM6 K 250 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 K 250 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 250 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic C-term F 339 - s20c Y 404 C.s20c.14
Van-der-waals C-term F 339 - s20c Y 404 C.s20c.14
Hydrophobic TM3 A 132 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 132 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 K 253 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 253 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals C-term H 343 - S9 R 148 N.S9.08
Hydrophobic TM3 V 133 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 133 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 I 231 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 I 231 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 231 5x72 s15s16 F 245 C.s15s16.03
Polar C-term H 343 - s9s10 S 159 N.s9s10.10
Van-der-waals C-term H 343 - s9s10 S 159 N.s9s10.10
Hydrophobic TM5 I 231 5x72 S6 R 77 N.S6.02
Hydrophobic TM6 L 258 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 258 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 133 3x54 s5s6 L 69 N.s5s6.05
Ionic C-term E 341 - s9s10 K 161 N.s9s10.12
Polar C-term E 341 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 341 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 341 - s9s10 K 161 N.s9s10.12
Polar TM5 H 233 5x74 S6 K 78 N.S6.03
Hydrophobic TM5 H 233 5x74 S6 K 78 N.S6.03
Van-der-waals TM5 H 233 5x74 S6 K 78 N.S6.03
Hydrophobic TM5 H 227 5x68 S5 Y 64 N.S5.12
Polar C-term A 342 - S10 R 166 N.S10.03
Van-der-waals C-term A 342 - S10 R 166 N.S10.03
Polar H8 W 315 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 W 315 8x49 s5s6 E 67 N.s5s6.03
Ionic ICL3 K 243 - S6 D 79 N.S6.04
Polar ICL3 K 243 - S6 D 79 N.S6.04
Hydrophobic ICL3 K 243 - S6 D 79 N.S6.04
Van-der-waals ICL3 K 243 - S6 D 79 N.S6.04
Polar TM4 N 145 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 N 145 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 P 65 2x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 P 65 2x38 s5s6 R 66 N.s5s6.02
Polar TM6 K 253 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 137 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 137 34x51 S16 A 248 C.S16.01
Aromatic TM5 H 227 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 H 227 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 H 227 5x68 S6 F 76 N.S6.01
Polar TM6 A 254 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 254 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 254 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 T 238 5x79 S6 I 82 N.S6.07
Hydrophobic ICL3 V 242 - s9s10 L 155 N.s9s10.03
Hydrophobic ICL1 Q 61 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 Q 61 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 137 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 137 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 H 138 34x52 S16 A 248 C.S16.01
Hydrophobic TM6 A 254 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 S 224 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 S 224 5x65 s5s6 L 74 N.s5s6.10
Aromatic TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic H8 N 313 8x47 s5s6 V 71 N.s5s6.07
Polar ICL3 K 243 - S5 T 59 N.S5.07
Hydrophobic ICL3 K 243 - S6 I 82 N.S6.07
Van-der-waals ICL3 K 243 - S6 I 82 N.S6.07
Polar TM5 T 238 5x79 S6 L 80 N.S6.05
Polar TM6 K 253 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 253 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 V 230 5x71 s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 V 242 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 V 242 - s9s10 E 156 N.s9s10.07
Polar TM2 S 64 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 64 2x37 s5s6 D 68 N.s5s6.04
Polar TM5 V 230 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 V 230 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 V 230 5x71 S6 K 78 N.S6.03
Hydrophobic TM6 T 257 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 T 140 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 T 140 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 I 220 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 133 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 137 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 137 34x51 S15 I 242 C.S15.14
Polar ICL2 L 137 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 137 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 137 34x51 S16 Y 250 C.S16.03
Hydrophobic H8 W 315 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 W 315 8x49 s5s6 D 68 N.s5s6.04