Beta-arrestin-1 - TAAR5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAAR5 80.0
Beta-arrestin-1 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 247 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 S 308 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 132 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 132 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 L 236 - S6 D 78 N.S6.04
Hydrophobic ICL2 L 140 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 140 34x51 S8 L 129 N.S8.03
Hydrophobic TM6 T 253 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 240 6x23 S6 V 81 N.S6.07
Van-der-waals TM6 L 240 6x23 S6 V 81 N.S6.07
Polar C-term Q 336 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term Q 336 - s9s10 K 160 N.s9s10.12
Polar TM3 D 138 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 D 138 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 136 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 136 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 139 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 139 34x50 S5 Y 63 N.S5.12
Hydrophobic TM6 A 250 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 250 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 140 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 140 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL3 L 236 - S6 K 77 N.S6.03
Van-der-waals ICL3 L 236 - S6 K 77 N.S6.03
Hydrophobic TM3 I 136 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 P 143 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 143 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 140 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 140 34x51 S5 Y 63 N.S5.12
Hydrophobic TM3 A 135 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 233 5x72 S6 K 77 N.S6.03
Hydrophobic TM6 A 250 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 250 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic H8 Y 309 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 233 5x72 S6 R 76 N.S6.02
Hydrophobic ICL2 L 140 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 140 34x51 S15 I 241 C.S15.14
Polar TM5 Q 232 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 Q 232 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 Q 232 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 Q 229 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 229 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 L 236 - s17s18 I 314 C.s17s18.40
Hydrophobic ICL2 L 140 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 L 140 34x51 S9 C 140 N.S9.01
Hydrophobic TM4 T 147 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 T 147 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic H8 W 311 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 139 34x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 233 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 I 233 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic H8 W 311 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 W 311 8x49 s5s6 D 67 N.s5s6.04
Polar TM5 Q 232 5x71 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 232 5x71 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 A 250 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 250 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 240 6x23 S6 D 78 N.S6.04
Hydrophobic ICL2 L 141 34x52 S16 Y 249 C.S16.03
Ionic C-term E 337 - s9s10 K 157 N.s9s10.09
Polar C-term E 337 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term E 337 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term E 337 - s9s10 K 157 N.s9s10.09
Polar C-term Q 336 - s20c E 404 C.s20c.14
Hydrophobic ICL2 P 143 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 P 143 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 L 236 - S6 L 79 N.S6.05
Van-der-waals ICL3 L 236 - S6 L 79 N.S6.05
Hydrophobic TM6 L 254 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 254 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 S 144 34x55 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 S 144 34x55 s8s9 D 135 N.s8s9.06
Polar TM3 C 137 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 137 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic C-term Y 335 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term Y 335 - s5s6 D 67 N.s5s6.04
Hydrophobic TM5 A 226 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 226 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Y 142 34x53 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 Y 142 34x53 s5s6 L 68 N.s5s6.05
Polar C-term E 337 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term E 337 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term E 337 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 P 139 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM5 Q 229 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 229 5x68 S6 F 75 N.S6.01
Hydrophobic TM3 A 135 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 135 3x53 s5s6 L 68 N.s5s6.05