Beta-arrestin-1 - TAAR8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAAR8 82.8
Beta-arrestin-1 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 132 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 V 132 3x53 s5s6 V 70 N.s5s6.07
Polar TM3 T 134 3x55 S5 Y 63 N.S5.12
Hydrophobic TM3 V 133 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 262 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 262 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 Y 216 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 137 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 137 34x51 S8 L 129 N.S8.03
Hydrophobic H8 W 316 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 W 316 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 W 316 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 W 316 8x49 s5s6 D 67 N.s5s6.04
Polar C-term E 342 - S10 R 165 N.S10.03
Hydrophobic C-term E 342 - S10 R 165 N.S10.03
Van-der-waals C-term E 342 - S10 R 165 N.S10.03
Ionic C-term E 342 - s9s10 K 160 N.s9s10.12
Polar C-term E 342 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term E 342 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term E 342 - s9s10 K 160 N.s9s10.12
Hydrophobic TM5 T 233 5x75 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 T 233 5x75 s17s18 I 314 C.s17s18.40
Hydrophobic ICL2 Y 139 34x53 s5s6 R 65 N.s5s6.02
Polar ICL3 S 239 - S6 V 81 N.S6.07
Van-der-waals ICL3 S 239 - S6 V 81 N.S6.07
Hydrophobic TM5 Q 226 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 226 5x68 s15s16 F 244 C.s15s16.03
Polar TM6 R 247 6x25 s9s10 E 156 N.s9s10.08
Hydrophobic TM3 R 129 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 129 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 137 34x51 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 L 137 34x51 s8s9 A 139 N.s8s9.10
Polar TM5 T 233 5x75 S6 K 77 N.S6.03
Hydrophobic TM5 T 233 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 T 233 5x75 S6 K 77 N.S6.03
Hydrophobic TM5 I 230 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 I 230 5x72 s15s16 F 244 C.s15s16.03
Ionic TM6 R 251 6x29 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 L 259 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 259 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 A 140 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 140 34x54 s5s6 R 65 N.s5s6.02
Polar TM6 R 251 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 251 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 251 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 T 141 34x55 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 T 141 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 Y 139 34x53 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 Y 139 34x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 V 132 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 132 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL3 S 239 - S6 F 80 N.S6.06
Van-der-waals ICL3 S 239 - S6 F 80 N.S6.06
Hydrophobic TM3 V 133 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 L 137 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 L 137 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 P 136 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 A 255 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 255 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 137 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 137 34x51 S15 I 241 C.S15.14
Polar TM6 T 258 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 258 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 258 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 V 237 5x79 S6 L 79 N.S6.05
Van-der-waals TM5 V 237 5x79 S6 L 79 N.S6.05
Hydrophobic ICL2 P 136 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 136 34x50 S5 Y 63 N.S5.12
Hydrophobic TM6 A 255 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 255 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 137 34x51 S5 Y 63 N.S5.12
Hydrophobic C-term E 342 - s20c E 405 C.s20c.15
Van-der-waals C-term E 342 - s20c E 405 C.s20c.15
Polar ICL3 Y 244 - S6 D 78 N.S6.04
Hydrophobic ICL3 Y 244 - S6 D 78 N.S6.04
Van-der-waals ICL3 Y 244 - S6 D 78 N.S6.04
Polar TM6 R 247 6x25 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 R 247 6x25 s9s10 E 155 N.s9s10.07
Polar TM3 D 135 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 D 135 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 230 5x72 S6 K 77 N.S6.03
Hydrophobic C-term F 340 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term F 340 - s5s6 D 67 N.s5s6.04
Hydrophobic TM5 V 237 5x79 S6 F 80 N.S6.06
Hydrophobic H8 Y 314 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Y 314 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Q 226 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 226 5x68 S6 F 75 N.S6.01
Polar C-term S 338 - s20c E 405 C.s20c.15
Hydrophobic C-term S 338 - s20c E 405 C.s20c.15
Van-der-waals C-term S 338 - s20c E 405 C.s20c.15
Polar TM3 T 134 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 T 134 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 137 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 137 34x51 S16 Y 249 C.S16.03
Polar H8 Y 314 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic H8 Y 314 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 Y 314 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 A 223 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 223 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 A 140 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 A 140 34x54 s8s9 D 135 N.s8s9.06