Beta-arrestin-2 - TAAR9 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAAR9 81.9
Beta-arrestin-2 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 Y 315 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 Y 315 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 Y 315 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 Y 140 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 140 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 A 263 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 263 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 341 - s5s6 D 68 N.s5s6.04
Ionic C-term D 348 - s20c R 395 C.s20c.05
Hydrophobic C-term D 348 - s20c D 405 C.s20c.15
Polar C-term E 346 - S1 K 12 N.S1.04
Van-der-waals C-term E 346 - S1 K 12 N.S1.04
Hydrophobic ICL2 L 138 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 138 34x51 S15 I 242 C.S15.14
Hydrophobic H8 W 317 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 W 317 8x49 s5s6 D 68 N.s5s6.04
Polar H8 Y 315 8x47 s5s6 L 72 N.s5s6.08
Van-der-waals H8 Y 315 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 134 3x54 S6 F 76 N.S6.01
Polar C-term T 347 - s17s18 K 295 C.s17s18.20
Polar ICL2 L 138 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 138 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 138 34x51 S16 Y 250 C.S16.03
Ionic C-term E 346 - s9s10 K 161 N.s9s10.12
Polar C-term E 346 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 346 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 346 - s9s10 K 161 N.s9s10.12
Polar ICL1 Q 62 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 P 137 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic C-term V 345 - S10 R 166 N.S10.03
Hydrophobic TM5 T 234 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 T 234 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic TM3 R 130 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 130 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 260 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 260 6x37 s5s6 L 72 N.s5s6.08
Polar C-term N 339 - s20c Y 404 C.s20c.14
Hydrophobic C-term N 339 - s20c Y 404 C.s20c.14
Van-der-waals C-term N 339 - s20c Y 404 C.s20c.14
Hydrophobic H8 Y 315 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Y 315 8x47 s5s6 V 71 N.s5s6.07
Polar ICL3 Y 245 - S6 D 79 N.S6.04
Hydrophobic ICL3 Y 245 - S6 D 79 N.S6.04
Van-der-waals ICL3 Y 245 - S6 D 79 N.S6.04
Hydrophobic C-term E 344 - s5s6 E 67 N.s5s6.03
Van-der-waals C-term E 344 - s5s6 E 67 N.s5s6.03
Hydrophobic TM5 I 231 5x72 S6 K 78 N.S6.03
Hydrophobic TM3 V 134 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 231 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 231 5x72 s15s16 F 245 C.s15s16.03
Polar C-term T 338 - s20c Y 404 C.s20c.14
Hydrophobic C-term T 338 - s20c Y 404 C.s20c.14
Van-der-waals C-term T 338 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 138 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 L 138 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 A 133 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 133 3x53 s5s6 L 69 N.s5s6.05
Polar C-term T 347 - s17s18 K 293 C.s17s18.18
Hydrophobic C-term T 347 - s17s18 K 293 C.s17s18.18
Van-der-waals C-term T 347 - s17s18 K 293 C.s17s18.18
Hydrophobic C-term V 345 - S10 V 168 N.S10.05
Polar TM6 R 248 6x25 s9s10 L 155 N.s9s10.03
Van-der-waals TM6 R 248 6x25 s9s10 L 155 N.s9s10.03
Polar ICL2 T 139 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 T 139 34x52 S16 Y 250 C.S16.03
Polar TM5 Q 237 5x78 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 Q 237 5x78 s17s18 N 312 C.s17s18.37
Hydrophobic ICL2 P 137 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 A 256 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 256 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 347 - S10 V 168 N.S10.05
Van-der-waals C-term T 347 - S10 V 168 N.S10.05
Hydrophobic C-term T 347 - s8s9 K 139 N.s8s9.09
Hydrophobic H8 W 317 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 P 141 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 141 34x54 s5s6 R 66 N.s5s6.02
Ionic TM5 K 230 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 230 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 230 5x71 s17s18 E 314 C.s17s18.39
Polar C-term D 348 - S1 K 12 N.S1.04
Van-der-waals C-term D 348 - S1 K 12 N.S1.04
Hydrophobic C-term D 348 - s20c A 392 C.s20c.02
Van-der-waals C-term D 348 - s20c A 392 C.s20c.02
Hydrophobic TM5 Q 227 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 Q 227 5x68 S6 F 76 N.S6.01
Polar ICL3 S 240 - S6 I 82 N.S6.07
Van-der-waals C-term D 348 - s20c R 393 C.s20c.03
Hydrophobic TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 Y 245 - S6 I 82 N.S6.07
Van-der-waals ICL3 Y 245 - S6 I 82 N.S6.07
Polar C-term E 344 - s9s10 K 161 N.s9s10.12
Polar C-term T 337 - s20c Y 404 C.s20c.14
Hydrophobic C-term T 337 - s20c Y 404 C.s20c.14
Van-der-waals C-term T 337 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 Y 140 34x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 141 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 141 34x54 s8s9 D 136 N.s8s9.06
Ionic C-term D 348 - s17s18 K 295 C.s17s18.20
Polar C-term D 348 - s17s18 K 295 C.s17s18.20
Van-der-waals C-term D 348 - s17s18 K 295 C.s17s18.20
Hydrophobic ICL2 L 138 34x51 s8s9 A 140 N.s8s9.10
Hydrophobic ICL2 P 137 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 138 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 138 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 Y 217 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 138 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 A 224 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 224 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 Q 227 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 227 5x68 s15s16 F 245 C.s15s16.03
Polar TM5 T 234 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 T 234 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 T 234 5x75 S6 K 78 N.S6.03
Hydrophobic C-term V 345 - S5 R 63 N.S5.11
Polar C-term S 342 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term S 342 - s9s10 K 161 N.s9s10.12
Polar TM2 T 65 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 A 238 5x79 S6 L 80 N.S6.05
Van-der-waals TM5 A 238 5x79 S6 L 80 N.S6.05
Hydrophobic C-term V 345 - S9 E 146 N.S9.06
Van-der-waals C-term V 345 - S9 E 146 N.S9.06
Hydrophobic ICL2 L 138 34x51 S8 L 130 N.S8.03
Polar TM5 K 230 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 K 230 5x71 S6 K 78 N.S6.03
Hydrophobic TM6 A 256 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 256 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 A 256 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 A 256 6x33 s5s6 G 73 N.s5s6.09
Polar C-term E 343 - S10 R 166 N.S10.03
Van-der-waals C-term E 343 - S10 R 166 N.S10.03
Polar TM6 T 259 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 259 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 259 6x36 s5s6 L 72 N.s5s6.08