Beta-arrestin-1 - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TPRA1 55.2
Beta-arrestin-1 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term C 296 - S16 Q 248 C.S16.02
Van-der-waals C-term C 296 - S16 Q 248 C.S16.02
Hydrophobic C-term Y 294 - s8s9 G 137 N.s8s9.08
Van-der-waals C-term Y 294 - s8s9 G 137 N.s8s9.08
Polar C-term Q 297 - s8s9 D 135 N.s8s9.06
Hydrophobic C-term Q 297 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term Q 297 - s8s9 D 135 N.s8s9.06
Ionic C-term D 299 - s17s18 K 284 C.s17s18.10
Polar C-term D 299 - s17s18 K 284 C.s17s18.10
Hydrophobic C-term D 299 - s17s18 K 284 C.s17s18.10
Van-der-waals C-term D 299 - s17s18 K 284 C.s17s18.10
Hydrophobic C-term N 372 - S19 P 348 C.S19.08
Van-der-waals C-term N 372 - S19 P 348 C.S19.08
Polar C-term D 299 - S16 C 251 C.S16.05
Hydrophobic C-term D 299 - S16 C 251 C.S16.05
Van-der-waals C-term D 299 - S16 C 251 C.S16.05
Hydrophobic TM4 I 154 4x48 s18s19 L 335 C.s18s19.06
Polar C-term A 373 - S18 K 322 C.S18.06
Van-der-waals C-term A 373 - S18 K 322 C.S18.06
Hydrophobic C-term Y 294 - S16 A 247 C.S16.01
Van-der-waals C-term Y 294 - S16 A 247 C.S16.01
Hydrophobic C-term C 296 - S16 Y 249 C.S16.03
Van-der-waals C-term C 296 - S16 Y 249 C.S16.03
Polar C-term F 292 - S16 A 247 C.S16.01
Hydrophobic C-term F 292 - S16 A 247 C.S16.01
Van-der-waals C-term F 292 - S16 A 247 C.S16.01
Polar C-term Y 294 - S5 Y 63 N.S5.12
Hydrophobic C-term Y 294 - S5 Y 63 N.S5.12
Van-der-waals C-term Y 294 - S5 Y 63 N.S5.12
Hydrophobic C-term D 299 - S16 P 252 C.S16.06
Van-der-waals C-term D 299 - S16 P 252 C.S16.06
Hydrophobic C-term L 291 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term L 291 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term Y 294 - S16 Y 249 C.S16.03
Van-der-waals C-term Y 294 - S16 Y 249 C.S16.03
Hydrophobic TM4 A 153 4x47 s18s19 L 338 C.s18s19.09
Polar C-term S 293 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term S 293 - s15s16 T 246 C.s15s16.05
Polar C-term C 296 - s17s18 G 286 C.s17s18.12
Polar C-term Q 297 - s8s9 E 134 N.s8s9.05
Hydrophobic C-term Q 297 - s8s9 E 134 N.s8s9.05
Van-der-waals C-term Q 297 - s8s9 E 134 N.s8s9.05
Hydrophobic C-term Q 297 - s8s9 G 132 N.s8s9.03
Van-der-waals C-term Q 297 - s8s9 G 132 N.s8s9.03
Hydrophobic C-term Y 294 - S15 I 241 C.S15.14
Polar C-term C 296 - S16 K 250 C.S16.04
Hydrophobic C-term C 296 - S16 K 250 C.S16.04
Van-der-waals C-term C 296 - S16 K 250 C.S16.04
Hydrophobic TM4 I 154 4x48 s18s19 A 339 C.s18s19.10
Polar C-term Y 294 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term Y 294 - s15s16 N 245 C.s15s16.04
Van-der-waals C-term Y 294 - s15s16 N 245 C.s15s16.04
Hydrophobic TM4 R 150 4x44 s18s19 L 338 C.s18s19.09
Van-der-waals TM4 R 150 4x44 s18s19 L 338 C.s18s19.09
Polar TM4 R 150 4x44 s18s19 D 337 C.s18s19.08
Hydrophobic TM4 R 150 4x44 s18s19 D 337 C.s18s19.08
Van-der-waals TM4 R 150 4x44 s18s19 D 337 C.s18s19.08
Polar C-term C 296 - S16 C 251 C.S16.05
Hydrophobic C-term C 296 - S16 C 251 C.S16.05
Polar C-term Y 294 - S16 Q 248 C.S16.02
Van-der-waals C-term Y 294 - S16 Q 248 C.S16.02
Hydrophobic C-term S 293 - S16 A 247 C.S16.01
Polar TM4 R 150 4x44 s18s19 S 340 C.s18s19.11
Van-der-waals TM4 R 150 4x44 s18s19 S 340 C.s18s19.11
Hydrophobic C-term F 292 - s15s16 N 245 C.s15s16.04
Van-der-waals C-term F 292 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 137 3x55 s11s12 L 191 C.s11s12.02
Polar ICL2 H 141 - S11 R 188 C.S11.05
Aromatic ICL2 H 141 - S11 R 188 C.S11.05
Hydrophobic ICL2 H 141 - S11 R 188 C.S11.05
Van-der-waals ICL2 H 141 - S11 R 188 C.S11.05
Hydrophobic C-term W 368 - s10s11 R 177 C.s10s11.04
Van-der-waals C-term W 368 - s10s11 R 177 C.s10s11.04
Polar C-term F 292 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term F 292 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term F 292 - s15s16 T 246 C.s15s16.05
Polar C-term Y 294 - s8s9 T 136 N.s8s9.07
Hydrophobic C-term Y 294 - s8s9 T 136 N.s8s9.07
Van-der-waals C-term Y 294 - s8s9 T 136 N.s8s9.07
Hydrophobic TM4 I 154 4x48 s18s19 L 338 C.s18s19.09
Van-der-waals TM4 I 154 4x48 s18s19 L 338 C.s18s19.09