Arrestin-C - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TPRA1 55.5
Arrestin-C 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term C 296 - s5s6 L 69 N.s5s6.10
Polar ICL1 A 70 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL1 A 70 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL1 I 74 - S16 Y 246 C.S16.03
Van-der-waals ICL1 I 74 - S16 Y 246 C.S16.03
Hydrophobic TM4 A 153 4x47 s18s19 L 335 C.s18s19.09
Van-der-waals TM4 A 153 4x47 s18s19 L 335 C.s18s19.09
Polar C-term Q 297 - S6 D 74 N.S6.04
Polar TM4 R 150 4x44 s18s19 D 334 C.s18s19.08
Hydrophobic TM4 R 150 4x44 s18s19 D 334 C.s18s19.08
Van-der-waals TM4 R 150 4x44 s18s19 D 334 C.s18s19.08
Hydrophobic TM4 I 154 4x48 s18s19 L 335 C.s18s19.09
Hydrophobic C-term P 288 - s15s16 S 242 C.s15s16.04
Van-der-waals C-term P 288 - s15s16 S 242 C.s15s16.04
Ionic C-term E 302 - s9s10 R 158 N.s9s10.13
Hydrophobic ICL1 I 74 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL1 I 74 - s8s9 D 132 N.s8s9.06
Ionic TM4 R 150 4x44 S19 D 339 C.S19.02
Polar TM4 R 150 4x44 S19 D 339 C.S19.02
Hydrophobic ICL1 I 74 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 I 74 - s8s9 A 133 N.s8s9.07
Polar ICL1 S 76 - S16 T 247 C.S16.04
Polar C-term Y 294 - S6 R 72 N.S6.02
Hydrophobic C-term Y 294 - S6 R 72 N.S6.02
Van-der-waals C-term Y 294 - S6 R 72 N.S6.02
Polar ICL1 I 74 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 I 74 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 I 74 - s8s9 E 131 N.s8s9.05
Polar C-term I 290 - s15s16 Y 241 C.s15s16.03
Hydrophobic C-term I 290 - s15s16 Y 241 C.s15s16.03
Van-der-waals C-term I 290 - s15s16 Y 241 C.s15s16.03
Hydrophobic C-term E 302 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term V 298 - s5s6 G 68 N.s5s6.09
Hydrophobic C-term K 289 - s15s16 L 243 C.s15s16.05
Polar C-term Y 294 - S6 K 73 N.S6.03
Hydrophobic C-term Y 294 - S6 K 73 N.S6.03
Van-der-waals C-term Y 294 - S6 K 73 N.S6.03
Hydrophobic TM4 R 150 4x44 s18s19 L 335 C.s18s19.09
Van-der-waals TM4 R 150 4x44 s18s19 L 335 C.s18s19.09
Polar C-term C 296 - s5s6 G 68 N.s5s6.09
Hydrophobic C-term C 296 - s5s6 G 68 N.s5s6.09
Van-der-waals C-term C 296 - s5s6 G 68 N.s5s6.09
Hydrophobic ICL1 R 73 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 R 73 - s8s9 E 131 N.s8s9.05
Polar TM4 R 150 4x44 s18s19 A 337 C.s18s19.11
Hydrophobic TM4 R 150 4x44 s18s19 A 337 C.s18s19.11
Van-der-waals TM4 R 150 4x44 s18s19 A 337 C.s18s19.11
Hydrophobic C-term F 292 - s15s16 L 240 C.s15s16.02
Van-der-waals C-term F 292 - s15s16 L 240 C.s15s16.02
Hydrophobic C-term P 288 - s15s16 Y 241 C.s15s16.03
Van-der-waals C-term P 288 - s15s16 Y 241 C.s15s16.03
Hydrophobic C-term D 299 - s9s10 K 157 N.s9s10.12
Aromatic C-term F 292 - S6 K 73 N.S6.03
Hydrophobic C-term F 292 - S6 K 73 N.S6.03
Van-der-waals C-term F 292 - S6 K 73 N.S6.03
Hydrophobic C-term L 291 - s17s18 E 310 C.s17s18.39
Van-der-waals C-term L 291 - s17s18 E 310 C.s17s18.39
Polar C-term Y 294 - S6 F 71 N.S6.01
Aromatic C-term Y 294 - S6 F 71 N.S6.01
Hydrophobic C-term Y 294 - S6 F 71 N.S6.01
Van-der-waals C-term Y 294 - S6 F 71 N.S6.01
Polar C-term Q 297 - S6 R 72 N.S6.02
Hydrophobic C-term Q 297 - S6 R 72 N.S6.02
Van-der-waals C-term Q 297 - S6 R 72 N.S6.02
Polar C-term Y 294 - S5 F 57 N.S5.10
Van-der-waals C-term Y 294 - S5 F 57 N.S5.10
Polar C-term E 300 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term E 300 - s9s10 K 157 N.s9s10.12
Hydrophobic TM4 I 154 4x48 s18s19 T 336 C.s18s19.10
Polar C-term K 289 - s15s16 Y 241 C.s15s16.03
Hydrophobic C-term K 289 - s15s16 Y 241 C.s15s16.03
Van-der-waals C-term K 289 - s15s16 Y 241 C.s15s16.03
Polar C-term C 296 - s5s6 T 70 N.s5s6.11
Hydrophobic C-term C 296 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term C 296 - s5s6 T 70 N.s5s6.11