Beta-arrestin-2 - TRH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TRH1 75.5
Beta-arrestin-2 82.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 H 55 12x49 s8s9 T 137 N.s8s9.07
Polar C-term E 366 - s6h1 P 97 N.s6h1.10
Hydrophobic C-term E 366 - s6h1 P 97 N.s6h1.10
Van-der-waals C-term E 366 - s6h1 P 97 N.s6h1.10
Polar C-term F 363 - H1 R 100 N.H1.01
Hydrophobic C-term F 363 - H1 R 100 N.H1.01
Van-der-waals C-term F 363 - H1 R 100 N.H1.01
Polar ICL2 I 131 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 131 34x51 S16 Y 250 C.S16.03
Polar C-term T 380 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term T 380 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term T 380 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term F 363 - H1 L 106 N.H1.07
Van-der-waals C-term F 363 - H1 L 106 N.H1.07
Hydrophobic TM4 T 138 4x38 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 T 138 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM6 V 264 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic C-term K 358 - s19s20 D 383 C.s19s20.49
Van-der-waals C-term K 358 - s19s20 D 383 C.s19s20.49
Ionic C-term K 381 - S15 D 241 C.S15.13
Polar C-term K 381 - S15 D 241 C.S15.13
Van-der-waals C-term K 381 - S15 D 241 C.S15.13
Polar C-term S 355 - S20 F 388 C.S20.03
Hydrophobic C-term H 362 - s19s20 I 374 C.s19s20.39
Polar H8 S 324 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 324 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 324 8x47 s5s6 V 71 N.s5s6.07
Ionic C-term D 385 - S16 K 251 C.S16.04
Hydrophobic C-term T 365 - s6h1 T 99 N.s6h1.12
Van-der-waals C-term T 365 - s6h1 T 99 N.s6h1.12
Hydrophobic TM2 T 58 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic H8 K 326 8x49 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 Q 134 34x54 s5s6 R 66 N.s5s6.02
Polar C-term H 362 - H1 R 100 N.H1.01
Hydrophobic C-term H 362 - H1 R 100 N.H1.01
Van-der-waals C-term H 362 - H1 R 100 N.H1.01
Hydrophobic C-term V 372 - s7s8 P 121 N.s7s8.03
Hydrophobic TM5 L 218 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 218 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic C-term V 356 - S20 V 387 C.S20.02
Hydrophobic C-term K 381 - s15s16 T 247 C.s15s16.05
Polar C-term L 367 - s6h1 R 96 N.s6h1.09
Hydrophobic C-term L 367 - s6h1 R 96 N.s6h1.09
Van-der-waals C-term L 367 - s6h1 R 96 N.s6h1.09
Aromatic ICL2 F 135 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 135 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 135 34x55 S16 Y 250 C.S16.03
Polar ICL2 A 133 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 133 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 133 34x53 s5s6 R 66 N.s5s6.02
Polar TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic C-term Y 376 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term Y 376 - s17s18 N 312 C.s17s18.37
Ionic ICL1 K 54 12x48 s20c D 402 C.s20c.12
Polar ICL1 K 54 12x48 s20c D 402 C.s20c.12
Hydrophobic TM3 I 127 3x54 s5s6 L 74 N.s5s6.10
Polar C-term D 361 - s19s20 D 383 C.s19s20.49
Hydrophobic TM3 I 127 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 V 264 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 264 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 363 - H1 Q 102 N.H1.03
Van-der-waals C-term F 363 - H1 Q 102 N.H1.03
Polar ICL2 C 137 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 C 137 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 C 137 34x57 s5s6 R 66 N.s5s6.02
Polar C-term F 363 - s6h1 T 99 N.s6h1.12
Hydrophobic C-term F 363 - s6h1 T 99 N.s6h1.12
Van-der-waals C-term F 363 - s6h1 T 99 N.s6h1.12
Polar TM6 S 260 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 S 260 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 S 260 6x29 s5s6 G 73 N.s5s6.09
Polar C-term S 360 - H1 K 108 N.H1.09
Hydrophobic C-term S 360 - H1 K 108 N.H1.09
Van-der-waals C-term S 360 - H1 K 108 N.H1.09
Polar C-term S 383 - S16 K 251 C.S16.04
Ionic TM3 E 122 3x49 s5s6 R 66 N.s5s6.02
Polar C-term H 362 - H1 D 103 N.H1.04
Hydrophobic C-term H 362 - H1 D 103 N.H1.04
Van-der-waals C-term H 362 - H1 D 103 N.H1.04
Hydrophobic TM5 I 223 5x70 S6 F 76 N.S6.01
Van-der-waals TM5 I 223 5x70 S6 F 76 N.S6.01
Hydrophobic TM5 P 224 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 P 224 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 127 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 127 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic C-term H 362 - s19s20 F 376 C.s19s20.41
Ionic H8 K 326 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 326 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 326 8x49 s5s6 E 67 N.s5s6.03
Polar C-term T 365 - s6h1 P 97 N.s6h1.10
Van-der-waals C-term T 365 - s6h1 P 97 N.s6h1.10
Hydrophobic ICL2 I 131 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 131 34x51 S16 A 248 C.S16.01
Polar C-term E 366 - s6h1 R 96 N.s6h1.09
Hydrophobic C-term E 366 - s6h1 R 96 N.s6h1.09
Van-der-waals C-term E 366 - s6h1 R 96 N.s6h1.09
Hydrophobic C-term S 364 - s6h1 T 99 N.s6h1.12
Van-der-waals C-term S 364 - s6h1 T 99 N.s6h1.12
Hydrophobic TM5 P 227 5x74 S6 L 80 N.S6.05
Polar C-term T 365 - s6h1 P 98 N.s6h1.11
Hydrophobic C-term T 365 - s6h1 P 98 N.s6h1.11
Van-der-waals C-term T 365 - s6h1 P 98 N.s6h1.11
Van-der-waals TM3 A 126 3x53 s5s6 R 66 N.s5s6.02
Polar C-term E 359 - ns1 T 7 N.ns1.14
Hydrophobic C-term E 359 - ns1 T 7 N.ns1.14
Van-der-waals C-term E 359 - ns1 T 7 N.ns1.14
Van-der-waals C-term E 359 - ns1 G 6 N.ns1.13
Hydrophobic TM4 F 139 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 F 139 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 P 130 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic C-term Y 376 - s17s18 V 315 C.s17s18.40
Van-der-waals C-term Y 376 - s17s18 V 315 C.s17s18.40
Hydrophobic TM3 R 123 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 123 3x50 s5s6 L 72 N.s5s6.08
Polar TM4 S 140 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 R 261 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic C-term D 386 - S16 K 251 C.S16.04
Van-der-waals C-term D 386 - S16 K 251 C.S16.04
Polar H8 K 333 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 K 333 8x56 s20c Y 404 C.s20c.14
Hydrophobic C-term L 377 - s17s18 E 314 C.s17s18.39
Polar C-term S 360 - H1 R 104 N.H1.05
Hydrophobic C-term S 360 - H1 R 104 N.H1.05
Van-der-waals C-term S 360 - H1 R 104 N.H1.05
Hydrophobic TM5 P 227 5x74 S6 D 79 N.S6.04
Van-der-waals TM5 P 227 5x74 S6 D 79 N.S6.04
Polar C-term F 384 - S16 K 251 C.S16.04
Van-der-waals C-term F 384 - S16 K 251 C.S16.04
Polar C-term F 363 - H1 D 103 N.H1.04
Hydrophobic C-term F 363 - H1 D 103 N.H1.04
Van-der-waals C-term F 363 - H1 D 103 N.H1.04
Hydrophobic TM5 P 224 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 P 224 5x71 S6 K 78 N.S6.03
Hydrophobic C-term E 359 - s19s20 D 384 C.s19s20.50
Van-der-waals C-term E 359 - s19s20 D 384 C.s19s20.50
Ionic C-term D 361 - H1 R 107 N.H1.08
Polar C-term D 361 - H1 R 107 N.H1.08
Hydrophobic C-term D 361 - H1 R 107 N.H1.08
Van-der-waals C-term D 361 - H1 R 107 N.H1.08
Hydrophobic C-term I 357 - S20 F 388 C.S20.03
Van-der-waals C-term I 357 - S20 F 388 C.S20.03
Polar C-term K 358 - H1 K 108 N.H1.09
Hydrophobic C-term K 358 - H1 K 108 N.H1.09
Van-der-waals C-term K 358 - H1 K 108 N.H1.09
Polar C-term V 382 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term V 382 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term V 382 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term F 363 - s6h1 P 98 N.s6h1.11
Van-der-waals C-term F 363 - s6h1 P 98 N.s6h1.11
Hydrophobic ICL2 I 131 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 M 267 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 267 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic C-term V 356 - S20 I 386 C.S20.01
Van-der-waals C-term V 356 - S20 I 386 C.S20.01
Hydrophobic ICL2 F 135 34x55 S8 L 130 N.S8.03
Hydrophobic C-term H 362 - H1 R 107 N.H1.08
Van-der-waals C-term H 362 - H1 R 107 N.H1.08
Hydrophobic TM5 I 223 5x70 S6 R 77 N.S6.02
Polar ICL2 Q 134 34x54 S9 C 141 N.S9.01
Hydrophobic ICL2 Q 134 34x54 S9 C 141 N.S9.01
Van-der-waals ICL2 Q 134 34x54 S9 C 141 N.S9.01
Hydrophobic ICL2 F 135 34x55 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 F 135 34x55 s17s18 G 287 C.s17s18.12
Hydrophobic TM5 I 223 5x70 S5 Y 64 N.S5.12
Van-der-waals TM5 I 223 5x70 S5 Y 64 N.S5.12
Hydrophobic ICL3 T 249 - s9s10 L 155 N.s9s10.03
Polar C-term E 359 - s19s20 D 383 C.s19s20.49
Hydrophobic C-term E 359 - s19s20 D 383 C.s19s20.49
Van-der-waals C-term E 359 - s19s20 D 383 C.s19s20.49
Polar C-term D 361 - H1 R 104 N.H1.05
Hydrophobic C-term D 361 - H1 R 104 N.H1.05
Van-der-waals C-term D 361 - H1 R 104 N.H1.05
Polar ICL3 T 249 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 T 249 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 T 249 - s9s10 E 156 N.s9s10.07
Hydrophobic TM3 A 126 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 126 3x53 s5s6 L 69 N.s5s6.05
Ionic TM4 K 143 4x43 s8s9 E 135 N.s8s9.05
Hydrophobic C-term E 359 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term E 359 - s19s20 D 385 C.s19s20.51
Ionic H8 K 326 8x49 s5s6 D 70 N.s5s6.06
Polar H8 K 326 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 326 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 326 8x49 s5s6 D 70 N.s5s6.06
Polar C-term S 364 - H1 R 100 N.H1.01
Van-der-waals C-term S 364 - H1 R 100 N.H1.01
Polar ICL2 Q 134 34x54 s5s6 G 65 N.s5s6.01
Hydrophobic ICL2 Q 134 34x54 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 Q 134 34x54 s5s6 G 65 N.s5s6.01
Ionic C-term D 386 - S15 R 237 C.S15.09
Polar C-term I 357 - H1 K 108 N.H1.09
Hydrophobic C-term I 357 - H1 K 108 N.H1.09
Van-der-waals C-term I 357 - H1 K 108 N.H1.09
Polar C-term S 360 - s19s20 D 383 C.s19s20.49
Hydrophobic C-term S 360 - s19s20 D 383 C.s19s20.49
Van-der-waals C-term S 360 - s19s20 D 383 C.s19s20.49
Hydrophobic C-term S 364 - s6h1 P 98 N.s6h1.11
Hydrophobic ICL2 I 131 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic C-term V 372 - s7s8 N 123 N.s7s8.05
Van-der-waals C-term V 372 - s7s8 N 123 N.s7s8.05
Hydrophobic ICL2 P 130 34x50 S6 F 76 N.S6.01
Polar ICL3 R 252 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 252 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 252 - s9s10 E 156 N.s9s10.07
Hydrophobic C-term D 361 - H1 D 103 N.H1.04
Van-der-waals C-term D 361 - H1 D 103 N.H1.04
Polar ICL2 Q 134 34x54 s8s9 K 139 N.s8s9.09
Polar C-term K 358 - S20 I 386 C.S20.01
Hydrophobic C-term K 358 - S20 I 386 C.S20.01
Van-der-waals C-term K 358 - S20 I 386 C.S20.01
Hydrophobic C-term F 384 - S16 A 248 C.S16.01
Van-der-waals C-term F 384 - S16 A 248 C.S16.01
Hydrophobic ICL2 I 131 34x51 S5 Y 64 N.S5.12
Polar TM5 S 225 5x72 S6 D 79 N.S6.04
Van-der-waals TM5 S 225 5x72 S6 D 79 N.S6.04
Hydrophobic ICL1 K 54 12x48 s20c Y 404 C.s20c.14
Polar C-term I 357 - S20 I 386 C.S20.01
Hydrophobic C-term I 357 - S20 I 386 C.S20.01
Van-der-waals C-term I 357 - S20 I 386 C.S20.01
Hydrophobic C-term Y 354 - S20 V 387 C.S20.02
Polar C-term S 364 - s6h1 P 97 N.s6h1.10
Hydrophobic C-term S 364 - s6h1 P 97 N.s6h1.10
Van-der-waals C-term S 364 - s6h1 P 97 N.s6h1.10
Ionic C-term E 359 - H1 R 104 N.H1.05
Polar C-term E 359 - H1 R 104 N.H1.05
Hydrophobic C-term E 359 - H1 R 104 N.H1.05
Van-der-waals C-term E 359 - H1 R 104 N.H1.05
Hydrophobic C-term K 358 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term K 358 - s19s20 D 385 C.s19s20.51
Polar ICL1 H 55 12x49 s20c Y 404 C.s20c.14
Aromatic ICL1 H 55 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 H 55 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 H 55 12x49 s20c Y 404 C.s20c.14
Polar C-term A 379 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term A 379 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term A 379 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 P 130 34x50 S5 Y 64 N.S5.12
Hydrophobic C-term V 356 - s19s20 D 385 C.s19s20.51
Hydrophobic TM5 I 223 5x70 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 127 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 127 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic C-term E 359 - S20 I 386 C.S20.01
Van-der-waals C-term E 359 - S20 I 386 C.S20.01
Ionic C-term K 358 - s19s20 D 384 C.s19s20.50
Polar C-term K 358 - s19s20 D 384 C.s19s20.50
Hydrophobic C-term K 358 - s19s20 D 384 C.s19s20.50
Van-der-waals C-term K 358 - s19s20 D 384 C.s19s20.50
Van-der-waals C-term H 362 - H1 R 104 N.H1.05
Ionic C-term D 368 - s6h1 R 96 N.s6h1.09
Polar C-term D 368 - s6h1 R 96 N.s6h1.09
Hydrophobic C-term D 368 - s6h1 R 96 N.s6h1.09
Van-der-waals C-term D 368 - s6h1 R 96 N.s6h1.09
Polar C-term V 382 - S16 Q 249 C.S16.02
Polar TM4 F 139 4x39 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 I 131 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 131 34x51 S15 I 242 C.S15.14