Beta-arrestin-2 - TAS1R1 complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS1R1 80.9
Beta-arrestin-2 76.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 659 3x57 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 659 3x57 s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 835 - S16 A 248 C.S16.01
Aromatic TM3 F 660 3x58 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 F 660 3x58 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 F 660 3x58 s8s9 K 139 N.s8s9.09
Polar C-term Q 832 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term Q 832 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term Q 832 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term T 835 - s8s9 G 138 N.s8s9.08
Van-der-waals C-term T 835 - s8s9 G 138 N.s8s9.08
Polar ICL2 S 663 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 S 663 - s5s6 D 68 N.s5s6.04
Polar TM3 R 652 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 652 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 652 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic H8 F 827 8x54 s5s6 L 74 N.s5s6.10
Van-der-waals H8 F 827 8x54 s5s6 L 74 N.s5s6.10
Polar C-term Q 832 - s15s16 S 246 C.s15s16.04
Hydrophobic C-term Q 832 - s15s16 S 246 C.s15s16.04
Van-der-waals C-term Q 832 - s15s16 S 246 C.s15s16.04
Polar ICL2 P 667 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 P 667 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 598 12x51 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 R 598 12x51 s5s6 G 73 N.s5s6.09
Van-der-waals ICL1 R 598 12x51 s5s6 G 73 N.s5s6.09
Polar ICL2 S 663 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 663 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 663 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 664 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 664 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 Q 655 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Q 655 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic H8 Q 828 8x55 s15s16 F 245 C.s15s16.03
Van-der-waals H8 Q 828 8x55 s15s16 F 245 C.s15s16.03
Van-der-waals ICL1 R 598 12x51 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 Y 756 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 Y 756 - s5s6 L 74 N.s5s6.10
Hydrophobic TM3 F 660 3x58 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 Y 670 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 Y 670 - s20c Y 404 C.s20c.14
Polar TM3 I 659 3x57 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 I 659 3x57 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 Q 655 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 Y 756 - S6 F 76 N.S6.01
Van-der-waals ICL3 Y 756 - S6 F 76 N.S6.01
Polar TM3 R 652 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 652 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 V 674 - s5s6 V 71 N.s5s6.07
Van-der-waals ICL2 V 674 - s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 S 599 12x52 s5s6 L 74 N.s5s6.10
Van-der-waals ICL1 S 599 12x52 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 Y 756 - s5s6 L 69 N.s5s6.05
Ionic H8 E 825 8x52 S6 K 78 N.S6.03
Polar H8 E 825 8x52 S6 K 78 N.S6.03
Van-der-waals H8 E 825 8x52 S6 K 78 N.S6.03
Polar TM4 Q 675 4x28 s20c Q 407 C.s20c.17
Hydrophobic TM4 Q 675 4x28 s20c Q 407 C.s20c.17
Van-der-waals TM4 Q 675 4x28 s20c Q 407 C.s20c.17
Hydrophobic C-term I 831 - S6 F 76 N.S6.01
Van-der-waals C-term I 831 - S6 F 76 N.S6.01
Polar C-term Q 832 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term Q 832 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term Q 832 - s15s16 F 245 C.s15s16.03
Polar C-term T 835 - s8s9 T 137 N.s8s9.07
Hydrophobic C-term T 835 - s8s9 T 137 N.s8s9.07
Van-der-waals C-term T 835 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 P 595 12x48 s5s6 L 74 N.s5s6.10
Van-der-waals C-term T 835 - S16 Y 250 C.S16.03
Hydrophobic TM3 I 659 3x57 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 I 659 3x57 s5s6 D 68 N.s5s6.04
Polar ICL1 S 599 12x52 s5s6 L 72 N.s5s6.08
Polar C-term C 838 - s8s9 T 137 N.s8s9.07
Hydrophobic C-term C 838 - s8s9 T 137 N.s8s9.07
Van-der-waals C-term C 838 - s8s9 T 137 N.s8s9.07
Polar ICL2 H 671 - s20c Y 404 C.s20c.14
Aromatic ICL2 H 671 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 H 671 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 H 671 - s20c Y 404 C.s20c.14
Polar ICL2 T 664 - s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 T 664 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 T 664 - s8s9 P 134 N.s8s9.04
Hydrophobic C-term I 831 - S5 Y 64 N.S5.12
Hydrophobic TM3 I 659 3x57 s5s6 L 69 N.s5s6.05
Ionic ICL2 H 671 - s20c D 402 C.s20c.12
Hydrophobic H8 Q 828 8x55 S6 F 76 N.S6.01
Van-der-waals H8 Q 828 8x55 S6 F 76 N.S6.01
Polar C-term G 839 - s8s9 T 137 N.s8s9.07
Hydrophobic TM3 F 660 3x58 s5s6 L 72 N.s5s6.08
Hydrophobic C-term I 831 - s5s6 L 69 N.s5s6.05
Hydrophobic TM3 L 656 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 656 3x54 s5s6 L 72 N.s5s6.08
Polar C-term T 835 - S5 Y 64 N.S5.12
Polar ICL2 Y 670 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Y 670 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 Y 670 - s5s6 D 68 N.s5s6.04