Beta-arrestin-1 - TSH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TSH 76.9
Beta-arrestin-1 75.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 523 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 523 3x54 s5s6 L 73 N.s5s6.10
Ionic H8 K 683 8x48 s20c E 407 C.s20c.17
Polar H8 K 683 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 K 683 8x48 s20c E 407 C.s20c.17
Polar ICL2 R 528 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 528 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 528 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic C-term G 708 - s20c K 400 C.s20c.10
Polar C-term Q 709 - s20c E 405 C.s20c.15
Hydrophobic ICL2 M 527 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 M 527 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 L 629 6x40 s5s6 V 70 N.s5s6.07
Ionic TM3 E 518 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 E 518 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 E 518 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 E 518 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 M 527 34x51 S6 F 75 N.S6.01
Polar TM3 A 522 3x53 S5 Y 63 N.S5.12
Hydrophobic ICL2 R 528 34x52 S16 A 247 C.S16.01
Van-der-waals ICL2 R 528 34x52 S16 A 247 C.S16.01
Hydrophobic TM6 R 625 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 527 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 M 527 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 I 604 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 I 604 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic H8 A 684 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 A 684 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 R 625 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 R 625 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term Y 706 - s20c E 405 C.s20c.15
Van-der-waals C-term Y 706 - s20c E 405 C.s20c.15
Hydrophobic TM3 R 519 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic H8 T 682 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 T 682 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 523 3x54 S6 F 75 N.S6.01
Hydrophobic C-term V 711 - s20c M 399 C.s20c.09
Van-der-waals C-term V 711 - s20c M 399 C.s20c.09
Hydrophobic ICL2 M 527 34x51 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 M 527 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 M 527 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM7 Y 678 7x53 s5s6 V 70 N.s5s6.07
Ionic TM6 D 617 6x28 s9s10 K 157 N.s9s10.09
Polar TM6 D 617 6x28 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 D 617 6x28 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 D 617 6x28 s9s10 K 157 N.s9s10.09
Hydrophobic TM3 A 522 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 522 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 Y 444 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 Y 444 - s8s9 T 136 N.s8s9.07
Polar ICL2 D 530 34x54 S16 Q 248 C.S16.02
Hydrophobic ICL2 D 530 34x54 S16 Q 248 C.S16.02
Hydrophobic TM2 P 449 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 P 449 2x39 s5s6 D 67 N.s5s6.04
Polar ICL2 M 527 34x51 S16 A 247 C.S16.01
Hydrophobic ICL2 M 527 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 M 527 34x51 S16 A 247 C.S16.01
Polar H8 R 687 8x52 s8s9 T 136 N.s8s9.07
Hydrophobic H8 R 687 8x52 s8s9 T 136 N.s8s9.07
Polar C-term Q 709 - s20c D 402 C.s20c.12
Hydrophobic C-term Q 709 - s20c D 402 C.s20c.12
Van-der-waals C-term Q 709 - s20c D 402 C.s20c.12
Hydrophobic TM5 V 608 5x65 S6 F 75 N.S6.01
Hydrophobic TM6 R 625 6x36 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 625 6x36 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 529 34x53 S5 Y 63 N.S5.12
Hydrophobic TM6 L 629 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 629 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 Y 613 - S6 V 81 N.S6.07
Van-der-waals ICL3 Y 613 - S6 V 81 N.S6.07
Hydrophobic ICL2 M 527 34x51 S5 F 61 N.S5.10
Van-der-waals ICL2 M 527 34x51 S5 F 61 N.S5.10
Ionic H8 R 687 8x52 s5s6 E 66 N.s5s6.03
Polar H8 R 687 8x52 s5s6 E 66 N.s5s6.03
Hydrophobic H8 R 687 8x52 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 687 8x52 s5s6 E 66 N.s5s6.03
Polar ICL3 N 614 - s9s10 E 155 N.s9s10.07
Hydrophobic TM3 I 523 3x54 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 445 - s8s9 E 134 N.s8s9.05
Polar ICL1 K 445 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 K 445 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 K 445 - s8s9 E 134 N.s8s9.05
Hydrophobic TM6 I 622 6x33 s5s6 G 72 N.s5s6.09
Polar ICL2 A 526 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 526 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 526 34x50 S5 Y 63 N.S5.12
Hydrophobic TM2 P 449 2x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 P 449 2x39 s5s6 R 65 N.s5s6.02
Hydrophobic C-term G 708 - s20c D 402 C.s20c.12
Van-der-waals C-term G 708 - s20c D 402 C.s20c.12
Hydrophobic TM3 I 523 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 Y 601 5x58 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 Y 601 5x58 s5s6 L 71 N.s5s6.08
Ionic TM6 R 625 6x36 s5s6 D 69 N.s5s6.06
Polar TM6 R 625 6x36 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 R 625 6x36 s5s6 D 69 N.s5s6.06
Polar TM3 F 525 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 F 525 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 F 525 3x56 s15s16 N 245 C.s15s16.04
Ionic TM6 K 621 6x32 s20c E 407 C.s20c.17
Hydrophobic TM3 R 519 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 519 3x50 s5s6 V 70 N.s5s6.07
Polar H8 K 683 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 683 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 683 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 529 34x53 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 529 34x53 S16 Y 249 C.S16.03
Hydrophobic ICL2 D 530 34x54 S16 A 247 C.S16.01
Van-der-waals ICL2 D 530 34x54 S16 A 247 C.S16.01
Polar ICL2 R 528 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 R 528 34x52 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 528 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 T 607 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 T 607 5x64 s15s16 F 244 C.s15s16.03
Ionic ICL2 K 532 34x56 s8s9 D 135 N.s8s9.06
Polar ICL2 K 532 34x56 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 K 532 34x56 s8s9 D 135 N.s8s9.06
Hydrophobic TM5 I 604 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 L 677 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 677 7x52 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 M 626 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 V 608 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 V 608 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 I 622 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 622 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 519 3x50 s5s6 L 68 N.s5s6.05