S-arrestin - TSH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TSH 76.7
S-arrestin 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 K 621 6x32 s9s10 D 166 N.s9s10.08
Polar TM6 K 621 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 621 6x32 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 621 6x32 s9s10 D 166 N.s9s10.08
Ionic ICL2 K 532 34x56 s8s9 D 142 N.s8s9.06
Polar ICL2 K 532 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 K 532 34x56 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 K 532 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 K 618 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 K 618 6x29 S6 R 84 N.S6.02
Hydrophobic TM5 T 607 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL1 N 447 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 N 447 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 N 447 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 M 527 34x51 S5 F 69 N.S5.10
Van-der-waals ICL2 M 527 34x51 S5 F 69 N.S5.10
Van-der-waals H8 K 683 8x48 s5s6 T 82 N.s5s6.11
Hydrophobic TM5 V 608 5x65 S6 R 84 N.S6.02
Van-der-waals TM5 V 608 5x65 S6 R 84 N.S6.02
Hydrophobic ICL2 A 526 34x50 S9 C 147 N.S9.01
Polar ICL2 R 528 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 528 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 528 34x52 S16 Y 259 C.S16.03
Polar TM5 R 609 5x66 S6 R 85 N.S6.03
Polar TM7 F 681 7x56 s5s6 G 80 N.s5s6.09
Polar TM3 T 524 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 529 34x53 s17s18 G 296 C.s17s18.12
Hydrophobic TM7 Y 678 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic C-term V 711 - s17s18 K 304 C.s17s18.20
Hydrophobic TM6 R 625 6x36 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 M 626 6x37 S6 F 83 N.S6.01
Van-der-waals TM6 M 626 6x37 S6 F 83 N.S6.01
Polar TM6 R 625 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 625 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 R 625 6x36 s5s6 I 79 N.s5s6.08
Ionic TM6 K 618 6x29 S6 D 86 N.S6.04
Polar TM6 K 618 6x29 S6 D 86 N.S6.04
Hydrophobic TM6 K 618 6x29 S6 D 86 N.S6.04
Van-der-waals TM6 K 618 6x29 S6 D 86 N.S6.04
Polar ICL2 K 532 34x56 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 K 532 34x56 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 M 527 34x51 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 M 527 34x51 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 V 608 5x65 S6 R 85 N.S6.03
Van-der-waals TM5 V 608 5x65 S6 R 85 N.S6.03
Polar TM5 T 607 5x64 S5 Y 71 N.S5.12
Polar TM5 N 610 5x67 S6 D 86 N.S6.04
Van-der-waals TM5 N 610 5x67 S6 D 86 N.S6.04
Hydrophobic ICL1 Y 444 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 Y 444 - s8s9 S 143 N.s8s9.07
Ionic TM6 K 618 6x29 s9s10 E 165 N.s9s10.07
Polar TM6 K 618 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 K 618 6x29 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 K 618 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic ICL2 L 529 34x53 s17s18 R 295 C.s17s18.11
Polar ICL2 M 527 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 M 527 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 527 34x51 S16 Y 259 C.S16.03
Polar H8 T 682 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 T 682 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 682 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 L 629 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 629 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals H8 A 684 8x49 s5s6 D 75 N.s5s6.04
Ionic C-term K 714 - s20c D 389 C.s20c.08
Polar C-term K 714 - s20c D 389 C.s20c.08
Hydrophobic C-term K 714 - s20c D 389 C.s20c.08
Van-der-waals C-term K 714 - s20c D 389 C.s20c.08
Hydrophobic TM3 I 523 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 I 523 3x54 S5 Y 71 N.S5.12
Polar ICL3 Y 613 - S6 F 89 N.S6.07
Hydrophobic ICL3 Y 613 - S6 F 89 N.S6.07
Van-der-waals ICL3 Y 613 - S6 F 89 N.S6.07
Hydrophobic TM5 I 604 5x61 S6 F 83 N.S6.01
Van-der-waals TM5 I 604 5x61 S6 F 83 N.S6.01
Hydrophobic TM3 I 523 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 523 3x54 S6 F 83 N.S6.01
Ionic H8 R 687 8x52 s5s6 E 74 N.s5s6.03
Polar H8 R 687 8x52 s5s6 E 74 N.s5s6.03
Van-der-waals H8 R 687 8x52 s5s6 E 74 N.s5s6.03
Polar TM6 R 625 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 R 625 6x36 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 R 625 6x36 s5s6 G 80 N.s5s6.09
Polar TM7 L 677 7x52 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 L 677 7x52 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 L 677 7x52 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 A 526 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 526 34x50 S5 Y 71 N.S5.12
Hydrophobic TM5 I 606 5x63 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 R 519 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 519 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 M 527 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 M 527 34x51 S15 V 251 C.S15.14
Hydrophobic TM5 V 608 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 R 519 3x50 s5s6 I 76 N.s5s6.05
Polar TM5 T 607 5x64 S6 R 85 N.S6.03
Van-der-waals TM5 T 607 5x64 S6 R 85 N.S6.03
Ionic ICL2 D 530 34x54 S16 K 261 C.S16.05
Polar ICL2 D 530 34x54 S16 K 261 C.S16.05
Van-der-waals ICL2 D 530 34x54 S16 K 261 C.S16.05
Polar ICL1 K 445 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 K 445 - s8s9 Q 141 N.s8s9.05
Polar TM5 N 610 5x67 S6 L 87 N.S6.05
Hydrophobic TM3 A 522 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 522 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 V 608 5x65 S5 Y 71 N.S5.12
Hydrophobic TM3 I 523 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 M 527 34x51 S5 Y 71 N.S5.12
Polar TM6 D 617 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 D 617 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 D 617 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 Y 613 - S6 Y 88 N.S6.06
Van-der-waals ICL3 Y 613 - S6 Y 88 N.S6.06
Hydrophobic TM6 I 622 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 622 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 P 449 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic TM7 F 681 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 M 527 34x51 S9 C 147 N.S9.01
Ionic H8 K 683 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 683 8x48 s5s6 D 77 N.s5s6.06
Ionic ICL2 R 528 34x52 S16 D 257 C.S16.01
Polar ICL2 R 528 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 528 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 528 34x52 S16 D 257 C.S16.01
Hydrophobic TM6 M 626 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 629 6x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 L 629 6x40 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 M 527 34x51 S8 L 136 N.S8.03
Hydrophobic TM6 V 628 6x39 s5s6 I 79 N.s5s6.08