S-arrestin - UT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
UT 66.6
S-arrestin 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 Q 160 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 Q 160 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 Q 160 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 159 34x54 S5 Y 71 N.S5.12
Hydrophobic TM3 L 153 3x55 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 L 153 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL1 V 83 12x51 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 V 83 12x51 s5s6 D 75 N.s5s6.04
Polar TM6 R 250 6x27 S6 D 86 N.S6.04
Hydrophobic TM6 A 256 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 256 6x33 s5s6 I 79 N.s5s6.08
Aromatic TM6 F 246 6x23 s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 F 246 6x23 s7s8 Y 129 N.s7s8.05
Van-der-waals TM6 F 246 6x23 s7s8 Y 129 N.s7s8.05
Hydrophobic TM7 Y 315 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 315 7x53 s5s6 V 78 N.s5s6.07
Polar ICL2 R 161 34x56 s8s9 K 145 N.s8s9.09
Polar TM3 A 151 3x53 S5 Y 71 N.S5.12
Hydrophobic TM3 A 151 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 A 151 3x53 S5 Y 71 N.S5.12
Hydrophobic TM5 S 241 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 L 156 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 156 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 156 34x51 S16 Y 259 C.S16.03
Polar TM3 L 153 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 L 153 3x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 L 153 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM2 V 90 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 90 2x43 s5s6 V 78 N.s5s6.07
Polar ICL2 V 159 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 159 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 159 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 152 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 152 3x54 S6 F 83 N.S6.01
Polar ICL3 S 245 - S6 L 87 N.S6.05
Van-der-waals H8 R 331 8x59 s1s2 R 22 N.s1s2.02
Hydrophobic TM6 V 260 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 260 6x37 s5s6 I 79 N.s5s6.08
Polar TM6 R 250 6x27 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 250 6x27 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 250 6x27 s9s10 E 164 N.s9s10.06
Polar TM5 S 241 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 S 241 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 S 241 5x68 S6 R 85 N.S6.03
Hydrophobic TM6 L 259 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 259 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 260 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 M 144 3x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 M 86 2x39 s5s6 D 77 N.s5s6.06
Polar H8 R 320 8x48 s5s6 V 78 N.s5s6.07
Polar ICL3 S 245 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 245 - S6 D 86 N.S6.04
Hydrophobic TM2 M 86 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 M 86 2x39 s5s6 V 78 N.s5s6.07
Ionic TM6 R 250 6x27 s9s10 E 165 N.s9s10.07
Polar TM6 R 250 6x27 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 250 6x27 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 250 6x27 s9s10 E 165 N.s9s10.07
Hydrophobic TM2 S 85 2x38 s5s6 I 76 N.s5s6.05
Polar TM6 R 250 6x27 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 R 250 6x27 s9s10 A 163 N.s9s10.05
Hydrophobic TM6 I 263 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 263 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 M 86 2x39 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 M 86 2x39 s5s6 I 76 N.s5s6.05
Ionic H8 R 320 8x48 s5s6 E 74 N.s5s6.03
Polar H8 R 320 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic TM3 V 152 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 V 152 3x54 s15s16 Y 254 C.s15s16.03
Polar H8 R 320 8x48 s5s6 T 82 N.s5s6.11
Hydrophobic H8 R 320 8x48 s5s6 T 82 N.s5s6.11
Van-der-waals H8 R 320 8x48 s5s6 T 82 N.s5s6.11
Hydrophobic TM3 R 154 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 T 158 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 234 5x61 S6 F 83 N.S6.01
Ionic TM4 K 163 4x39 s8s9 D 142 N.s8s9.06
Polar TM4 K 163 4x39 s8s9 D 142 N.s8s9.06
Hydrophobic TM4 K 163 4x39 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 K 163 4x39 s8s9 D 142 N.s8s9.06
Polar H8 N 321 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 N 321 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 321 8x49 s5s6 D 75 N.s5s6.04
Polar TM2 S 85 2x38 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 S 85 2x38 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 S 85 2x38 s5s6 Q 73 N.s5s6.02
Polar ICL2 T 158 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 T 158 34x53 S5 Y 71 N.S5.12
Hydrophobic TM6 R 248 6x25 S6 F 89 N.S6.07
Polar ICL3 A 244 - S6 R 85 N.S6.03
Hydrophobic ICL3 A 244 - S6 R 85 N.S6.03
Van-der-waals ICL3 A 244 - S6 R 85 N.S6.03
Hydrophobic ICL2 L 156 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 156 34x51 S8 L 136 N.S8.03
Ionic TM3 R 148 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 148 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 148 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 148 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 A 249 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 A 249 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 A 256 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 256 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 156 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 156 34x51 S15 V 251 C.S15.14
Polar TM6 F 246 6x23 S6 L 87 N.S6.05
Polar ICL2 P 155 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 155 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 155 34x50 S5 Y 71 N.S5.12
Hydrophobic TM3 A 151 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 151 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 R 148 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 148 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 D 157 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 D 157 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 P 155 34x50 S15 V 251 C.S15.14
Polar TM2 S 85 2x38 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Polar TM4 K 163 4x39 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 K 163 4x39 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 K 163 4x39 s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 R 154 3x56 S16 D 257 C.S16.01
Van-der-waals TM3 R 154 3x56 S16 D 257 C.S16.01
Hydrophobic H8 T 319 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 T 319 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 155 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 155 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic H8 R 320 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 156 34x51 S16 D 257 C.S16.01