Gq - UT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
UT 70.3
Gαq 89.2
Gβ1 94.9
Gγ2 85.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 155 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 155 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 152 3x54 G.H5 L 358 G.H5.25
Polar TM2 S 85 2x38 G.H5 E 355 G.H5.22
Hydrophobic TM2 S 85 2x38 G.H5 E 355 G.H5.22
Van-der-waals TM2 S 85 2x38 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 156 34x51 G.H5 K 345 G.H5.12
Hydrophobic H8 T 319 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 T 319 8x47 G.H5 N 357 G.H5.24
Aromatic TM6 F 246 6x23 G.S6 Y 325 G.S6.02
Hydrophobic TM6 F 246 6x23 G.S6 Y 325 G.S6.02
Van-der-waals TM6 F 246 6x23 G.S6 Y 325 G.S6.02
Polar TM3 A 151 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 L 234 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM4 P 162 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 V 152 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 V 159 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 V 159 34x54 G.H5 I 348 G.H5.15
Polar ICL2 Q 160 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 Q 160 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 L 156 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 V 152 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 152 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 156 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM6 P 252 6x29 G.H5 V 359 G.H5.26
Ionic H8 R 320 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 R 320 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic H8 R 320 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 320 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM3 R 148 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 E 147 3x49 G.H5 Y 356 G.H5.23
Polar ICL2 Q 160 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 38 G.hns1.03
Polar TM3 R 148 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 156 34x51 G.H5 I 348 G.H5.15
Van-der-waals TM6 R 248 6x25 G.H4 V 314 G.H4.16
Hydrophobic H8 R 320 8x48 G.H5 K 354 G.H5.21
Polar TM3 R 148 3x50 G.H5 N 357 G.H5.24
Polar C-term S 369 - G.H4 E 307 G.H4.09
Hydrophobic C-term S 369 - G.H4 E 307 G.H4.09
Van-der-waals C-term S 369 - G.H4 E 307 G.H4.09
Polar TM6 R 255 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 255 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 155 34x50 G.H5 L 349 G.H5.16
Polar ICL2 T 158 34x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 T 158 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 Q 160 34x55 G.S3 V 199 G.S3.01
Hydrophobic TM2 M 86 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 86 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 155 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 348 G.H5.15
Polar H8 R 320 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 R 320 8x48 G.H5 N 357 G.H5.24
Hydrophobic TM6 A 256 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 260 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 155 34x50 G.H5 K 345 G.H5.12
Polar TM4 R 166 4x42 G.H5 Y 356 G.H5.23
Hydrophobic TM4 R 166 4x42 G.H5 Y 356 G.H5.23
Van-der-waals TM4 R 166 4x42 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 V 159 34x54 G.S1 L 40 G.S1.02
Polar TM6 R 250 6x27 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 R 250 6x27 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 R 250 6x27 G.h4s6 S 320 G.h4s6.11
Ionic TM6 R 248 6x25 G.H4 D 315 G.H4.17
Hydrophobic TM3 A 151 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 Y 356 G.H5.23
Polar H8 N 321 8x49 G.H5 E 355 G.H5.22
Ionic TM4 K 163 4x39 G.H5 E 355 G.H5.22
Polar TM4 K 163 4x39 G.H5 E 355 G.H5.22
Hydrophobic TM4 K 163 4x39 G.H5 E 355 G.H5.22
Van-der-waals TM4 K 163 4x39 G.H5 E 355 G.H5.22
Polar H8 N 321 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 N 321 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 N 321 8x49 G.H5 N 357 G.H5.24
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 F 246 6x23 G.H5 F 339 G.H5.06