Beta-arrestin-2 - V1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
V1A 70.5
Beta-arrestin-2 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 285 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 285 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 153 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 C 275 - S6 I 82 N.S6.07
Van-der-waals ICL3 C 275 - S6 I 82 N.S6.07
Hydrophobic ICL2 P 156 34x50 S6 F 76 N.S6.01
Hydrophobic TM4 A 164 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 A 164 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 160 34x54 S15 I 242 C.S15.14
Van-der-waals ICL2 L 160 34x54 S15 I 242 C.S15.14
Hydrophobic TM4 P 163 4x38 s8s9 D 136 N.s8s9.06
Van-der-waals TM4 P 163 4x38 s8s9 D 136 N.s8s9.06
Hydrophobic H8 S 352 8x47 s5s6 V 71 N.s5s6.07
Polar ICL3 V 276 - S6 D 79 N.S6.04
Hydrophobic ICL3 V 276 - S6 D 79 N.S6.04
Van-der-waals ICL3 V 276 - S6 D 79 N.S6.04
Hydrophobic TM3 A 152 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 152 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM6 A 285 6x29 s5s6 L 72 N.s5s6.08
Polar ICL3 S 277 - S6 D 79 N.S6.04
Van-der-waals ICL3 S 277 - S6 D 79 N.S6.04
Polar TM2 R 85 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 85 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 153 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 153 3x54 s5s6 L 72 N.s5s6.08
Polar TM6 R 288 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 R 288 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 288 6x32 s5s6 D 70 N.s5s6.06
Polar TM6 T 289 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 289 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 153 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 L 157 34x51 S16 A 248 C.S16.01
Polar TM5 K 250 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 K 250 5x72 S6 R 77 N.S6.02
Ionic ICL1 K 82 12x50 s20c D 402 C.s20c.12
Polar ICL1 K 82 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 82 12x50 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 82 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL3 P 274 - S6 I 82 N.S6.07
Van-der-waals ICL3 P 274 - S6 I 82 N.S6.07
Hydrophobic ICL2 L 157 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 156 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 156 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 I 243 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 243 5x65 s5s6 L 74 N.s5s6.10
Polar TM2 M 86 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 M 86 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 M 86 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 85 2x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 R 85 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 V 276 - S5 T 59 N.S5.07
Hydrophobic TM3 V 153 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 M 86 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 K 82 12x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 82 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 156 34x50 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 P 156 34x50 s5s6 G 65 N.s5s6.01
Ionic TM4 R 168 4x43 s8s9 E 135 N.s8s9.05
Polar TM4 R 168 4x43 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 168 4x43 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 168 4x43 s8s9 E 135 N.s8s9.05
Ionic H8 H 354 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 T 159 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 M 292 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 R 288 6x32 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 S 84 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM7 F 351 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 M 292 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 292 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 152 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 152 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 157 34x51 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 L 157 34x51 s15s16 L 244 C.s15s16.02
Polar ICL3 S 277 - S6 R 77 N.S6.02
Polar ICL2 L 157 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 157 34x51 S16 Y 250 C.S16.03
Polar TM6 R 288 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 R 288 6x32 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 R 288 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 285 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 A 285 6x29 s5s6 G 73 N.s5s6.09
Polar ICL2 Q 161 34x55 S16 Q 249 C.S16.02
Hydrophobic ICL3 V 276 - S6 R 77 N.S6.02
Hydrophobic TM2 S 84 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 84 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 157 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 157 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 149 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 160 34x54 S9 C 141 N.S9.01
Hydrophobic ICL2 Q 161 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 161 34x55 S16 Y 250 C.S16.03
Ionic C-term D 377 - s9s10 R 162 N.s9s10.13
Polar C-term D 377 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term D 377 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term D 377 - s9s10 R 162 N.s9s10.13
Hydrophobic ICL3 A 273 - S6 I 82 N.S6.07
Van-der-waals ICL3 A 273 - S6 I 82 N.S6.07
Ionic TM3 D 148 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 148 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 D 148 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 D 148 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 157 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 157 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 L 157 34x51 S9 C 141 N.S9.01
Ionic TM2 R 85 2x38 s8s9 D 136 N.s8s9.06
Polar TM2 R 85 2x38 s8s9 D 136 N.s8s9.06
Van-der-waals TM2 R 85 2x38 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 L 160 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 160 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL1 T 83 12x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 V 276 - S6 I 82 N.S6.07
Van-der-waals ICL3 V 276 - S6 I 82 N.S6.07