Beta-arrestin-2 - V1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
V1B 69.0
Beta-arrestin-2 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 275 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 275 6x29 s5s6 L 72 N.s5s6.08
Polar ICL2 L 140 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 140 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 143 34x54 S15 I 242 C.S15.14
Hydrophobic TM7 F 341 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 140 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 140 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 L 143 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 143 34x54 S16 Y 250 C.S16.03
Polar TM4 T 150 4x42 s8s9 E 135 N.s8s9.05
Polar TM6 R 278 6x32 s5s6 D 70 N.s5s6.06
Polar TM2 M 69 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 M 69 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 M 69 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 V 266 - S6 K 78 N.S6.03
Ionic TM2 R 68 2x38 s8s9 D 136 N.s8s9.06
Polar TM2 R 68 2x38 s8s9 D 136 N.s8s9.06
Hydrophobic TM2 R 68 2x38 s8s9 D 136 N.s8s9.06
Van-der-waals TM2 R 68 2x38 s8s9 D 136 N.s8s9.06
Hydrophobic TM3 R 132 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 139 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL3 R 265 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 265 - S6 I 82 N.S6.07
Hydrophobic ICL2 L 140 34x51 S9 C 141 N.S9.01
Hydrophobic ICL3 R 265 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 265 - S6 D 79 N.S6.04
Hydrophobic TM3 V 136 3x54 S6 F 76 N.S6.01
Hydrophobic TM2 R 68 2x38 s5s6 R 66 N.s5s6.02
Polar ICL3 V 266 - S6 D 79 N.S6.04
Hydrophobic ICL3 V 266 - S6 D 79 N.S6.04
Van-der-waals ICL3 V 266 - S6 D 79 N.S6.04
Polar TM6 T 279 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 279 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 136 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 140 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 140 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM4 G 147 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 G 147 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic H8 N 342 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 140 34x51 S5 Y 64 N.S5.12
Polar TM2 S 67 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 67 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 67 2x37 s5s6 D 68 N.s5s6.04
Aromatic ICL3 L 262 - S6 F 81 N.S6.06
Hydrophobic ICL3 L 262 - S6 F 81 N.S6.06
Van-der-waals ICL3 L 262 - S6 F 81 N.S6.06
Polar ICL2 Q 144 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 Q 144 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 144 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL1 R 66 12x51 s8s9 T 137 N.s8s9.07
Hydrophobic TM4 G 147 4x39 s17s18 R 286 C.s17s18.11
Hydrophobic TM6 R 278 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 R 132 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 262 - S6 I 82 N.S6.07
Van-der-waals ICL3 L 262 - S6 I 82 N.S6.07
Hydrophobic TM5 I 222 5x61 s5s6 L 72 N.s5s6.08
Ionic TM3 D 131 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 131 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 D 131 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 D 131 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 M 69 2x39 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 143 34x54 S8 L 130 N.S8.03
Hydrophobic ICL2 L 140 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 A 135 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 135 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 M 282 6x36 s5s6 L 72 N.s5s6.08
Polar TM2 R 68 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 68 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 136 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 136 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 275 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 275 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 139 34x50 S6 F 76 N.S6.01
Hydrophobic TM6 M 282 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 282 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM4 P 146 4x38 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 P 146 4x38 s17s18 R 286 C.s17s18.11
Polar ICL3 S 267 - S6 R 77 N.S6.02
Van-der-waals ICL3 S 267 - S6 R 77 N.S6.02
Ionic ICL1 K 65 12x50 s20c D 402 C.s20c.12
Polar ICL1 K 65 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 65 12x50 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 65 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL2 L 143 34x54 S9 C 141 N.S9.01
Van-der-waals ICL2 L 143 34x54 S9 C 141 N.S9.01
Ionic H8 H 344 8x49 s5s6 D 70 N.s5s6.06
Polar H8 H 344 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 H 344 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL1 K 65 12x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 65 12x50 s8s9 T 137 N.s8s9.07
Polar TM6 R 278 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 R 278 6x32 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 R 278 6x32 s5s6 V 71 N.s5s6.07
Polar ICL3 S 267 - s5s6 S 75 N.s5s6.11
Hydrophobic TM3 A 135 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 135 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 L 262 - S6 A 83 N.S6.08
Van-der-waals ICL3 L 262 - S6 A 83 N.S6.08
Polar ICL2 P 139 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic ICL2 P 139 34x50 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 P 139 34x50 s5s6 G 65 N.s5s6.01
Polar ICL3 R 265 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 265 - s9s10 L 155 N.s9s10.03
Hydrophobic TM3 V 136 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM4 Y 151 4x43 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 226 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 S 67 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 S 67 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 R 278 6x32 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 R 278 6x32 s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 L 140 34x51 s15s16 L 244 C.s15s16.02
Hydrophobic ICL1 R 64 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 64 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM2 M 69 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 M 69 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 S 264 - S6 I 82 N.S6.07
Hydrophobic TM6 A 275 6x29 s5s6 G 73 N.s5s6.09