Beta-arrestin-2 - V2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
V2 74.6
Beta-arrestin-2 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term C 358 - s20c L 408 C.s20c.18
Hydrophobic C-term S 362 - S20 E 389 C.S20.04
Hydrophobic TM5 I 228 5x61 s5s6 L 72 N.s5s6.08
Polar ICL2 G 151 34x57 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 G 151 34x57 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 A 140 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 140 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 R 137 3x50 s5s6 L 72 N.s5s6.08
Polar C-term C 358 - S1 K 12 N.S1.04
Hydrophobic C-term C 358 - S1 K 12 N.S1.04
Van-der-waals C-term C 358 - S1 K 12 N.S1.04
Polar ICL2 Y 148 34x54 S9 C 141 N.S9.01
Hydrophobic ICL2 Y 148 34x54 S9 C 141 N.S9.01
Hydrophobic TM2 P 73 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 73 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic C-term C 358 - s20c D 406 C.s20c.16
Van-der-waals C-term C 358 - s20c D 406 C.s20c.16
Hydrophobic TM6 M 272 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 272 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 A 72 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic C-term C 358 - s20c A 392 C.s20c.02
Van-der-waals C-term C 358 - s20c A 392 C.s20c.02
Polar C-term Q 354 - s20c Q 407 C.s20c.17
Van-der-waals C-term Q 354 - s20c Q 407 C.s20c.17
Hydrophobic TM4 G 153 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 G 153 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 P 73 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 P 240 5x73 S6 K 78 N.S6.03
Hydrophobic C-term T 359 - S20 D 390 C.S20.05
Van-der-waals C-term T 359 - S20 D 390 C.S20.05
Hydrophobic TM3 R 137 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 A 72 2x37 s5s6 D 68 N.s5s6.04
Polar C-term S 357 - S1 K 12 N.S1.04
Hydrophobic TM2 I 74 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 74 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 149 34x55 S16 Y 250 C.S16.03
Polar C-term A 361 - S20 D 390 C.S20.05
Hydrophobic C-term A 361 - S20 D 390 C.S20.05
Van-der-waals C-term A 361 - S20 D 390 C.S20.05
Polar TM6 T 269 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 269 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 269 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term L 365 - S20 F 388 C.S20.03
Van-der-waals C-term L 365 - S20 F 388 C.S20.03
Hydrophobic C-term S 364 - S20 V 387 C.S20.02
Hydrophobic TM4 G 153 4x39 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 G 153 4x39 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 S 235 5x68 s15s16 F 245 C.s15s16.03
Polar TM6 K 268 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 K 268 6x32 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 K 268 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 232 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 232 5x65 s5s6 L 74 N.s5s6.10
Polar TM5 R 243 5x76 s7s8 N 123 N.s7s8.05
Van-der-waals TM5 R 243 5x76 s7s8 N 123 N.s7s8.05
Hydrophobic C-term E 356 - s1s2 P 15 N.s1s2.02
Van-der-waals C-term E 356 - s1s2 P 15 N.s1s2.02
Hydrophobic TM7 F 328 7x56 s5s6 V 71 N.s5s6.07
Ionic ICL1 H 70 - s20c D 402 C.s20c.12
Hydrophobic ICL1 H 70 - s20c D 402 C.s20c.12
Polar C-term E 356 - S1 K 12 N.S1.04
Van-der-waals C-term E 356 - S1 K 12 N.S1.04
Polar C-term T 359 - s20c D 406 C.s20c.16
Hydrophobic C-term T 359 - s20c D 406 C.s20c.16
Van-der-waals C-term T 359 - s20c D 406 C.s20c.16
Hydrophobic ICL1 W 71 - s8s9 T 137 N.s8s9.07
Hydrophobic TM3 I 141 3x54 s5s6 L 74 N.s5s6.10
Aromatic ICL1 H 70 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 H 70 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 H 70 - s20c Y 404 C.s20c.14
Polar TM6 K 268 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 268 6x32 s5s6 D 70 N.s5s6.06
Ionic C-term E 356 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 356 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 356 - s9s10 K 161 N.s9s10.12
Polar C-term S 357 - s20c Q 407 C.s20c.17
Hydrophobic C-term S 357 - s20c Q 407 C.s20c.17
Van-der-waals C-term S 357 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 M 145 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 145 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 I 141 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 141 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 145 34x51 S5 Y 64 N.S5.12
Polar C-term D 355 - s20c Y 404 C.s20c.14
Hydrophobic C-term D 355 - s20c Y 404 C.s20c.14
Van-der-waals C-term D 355 - s20c Y 404 C.s20c.14
Hydrophobic C-term A 361 - s20c L 408 C.s20c.18
Van-der-waals C-term A 361 - s20c L 408 C.s20c.18
Hydrophobic H8 S 329 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 M 145 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 145 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 A 265 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 265 6x29 s5s6 L 74 N.s5s6.10
Polar C-term C 358 - S1 S 13 N.S1.05
Hydrophobic C-term C 358 - S1 S 13 N.S1.05
Van-der-waals C-term C 358 - S1 S 13 N.S1.05
Hydrophobic ICL2 Y 148 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 Y 148 34x54 S8 L 130 N.S8.03
Hydrophobic TM6 K 268 6x32 s5s6 G 73 N.s5s6.09
Polar C-term S 357 - s20c D 405 C.s20c.15
Hydrophobic C-term S 357 - s20c D 405 C.s20c.15
Van-der-waals C-term S 357 - s20c D 405 C.s20c.15
Hydrophobic TM3 A 140 3x53 s5s6 L 69 N.s5s6.05
Polar C-term T 359 - s20c L 408 C.s20c.18
Hydrophobic C-term T 359 - s20c L 408 C.s20c.18
Van-der-waals C-term T 359 - s20c L 408 C.s20c.18
Polar TM4 A 154 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 A 154 4x40 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 A 154 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 W 156 4x42 s8s9 D 136 N.s8s9.06
Van-der-waals TM4 W 156 4x42 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Y 148 34x54 s8s9 P 132 N.s8s9.02
Hydrophobic TM4 W 156 4x42 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 W 156 4x42 s8s9 E 135 N.s8s9.05
Polar C-term S 363 - S20 F 388 C.S20.03
Van-der-waals C-term S 363 - S20 F 388 C.S20.03
Hydrophobic TM3 I 141 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 141 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 141 3x54 S6 F 76 N.S6.01
Hydrophobic C-term T 360 - S20 E 389 C.S20.04
Ionic TM3 D 136 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 136 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 D 136 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 D 136 3x49 s5s6 R 66 N.s5s6.02
Polar C-term D 355 - s20c Q 407 C.s20c.17
Van-der-waals C-term D 355 - s20c Q 407 C.s20c.17
Hydrophobic TM6 K 268 6x32 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 268 6x32 s5s6 L 72 N.s5s6.08
Ionic C-term K 367 - s19s20 D 385 C.s19s20.51
Polar C-term K 367 - s19s20 D 385 C.s19s20.51
Hydrophobic C-term K 367 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term K 367 - s19s20 D 385 C.s19s20.51
Polar ICL2 R 149 34x55 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 R 149 34x55 s15s16 T 247 C.s15s16.05
Aromatic TM4 W 156 4x42 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 W 156 4x42 s5s6 R 66 N.s5s6.02
Polar C-term S 357 - s20c Y 404 C.s20c.14
Hydrophobic C-term S 357 - s20c Y 404 C.s20c.14
Van-der-waals C-term S 357 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 R 149 34x55 S16 A 248 C.S16.01
Hydrophobic ICL2 P 144 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 144 34x50 S5 Y 64 N.S5.12
Polar ICL2 M 145 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 145 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 145 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 148 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 Y 148 34x54 S16 Y 250 C.S16.03
Hydrophobic C-term S 362 - S20 F 388 C.S20.03
Van-der-waals C-term S 362 - S20 F 388 C.S20.03
Polar C-term C 358 - s20c Q 407 C.s20c.17
Hydrophobic C-term C 358 - s20c Q 407 C.s20c.17
Van-der-waals C-term C 358 - s20c Q 407 C.s20c.17
Hydrophobic C-term L 365 - H1 K 108 N.H1.09
Polar C-term E 356 - s20c D 405 C.s20c.15
Hydrophobic C-term E 356 - s20c D 405 C.s20c.15
Hydrophobic ICL2 M 145 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 M 145 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 M 145 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 145 34x51 S15 I 242 C.S15.14
Polar H8 S 330 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 330 8x48 s5s6 D 70 N.s5s6.06
Polar TM2 I 74 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 I 74 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 I 74 2x39 s5s6 D 68 N.s5s6.04
Polar C-term S 357 - s20c D 406 C.s20c.16
Hydrophobic C-term S 357 - s20c D 406 C.s20c.16
Van-der-waals C-term S 357 - s20c D 406 C.s20c.16
Polar C-term E 356 - s20c Y 404 C.s20c.14
Van-der-waals C-term E 356 - s20c Y 404 C.s20c.14
Hydrophobic TM6 A 265 6x29 s5s6 G 73 N.s5s6.09
Polar ICL3 E 258 - S6 D 79 N.S6.04
Hydrophobic ICL3 E 258 - S6 D 79 N.S6.04
Van-der-waals ICL3 E 258 - S6 D 79 N.S6.04
Polar C-term T 359 - s20c Q 407 C.s20c.17
Hydrophobic C-term T 359 - s20c Q 407 C.s20c.17
Van-der-waals C-term T 359 - s20c Q 407 C.s20c.17
Polar C-term T 360 - s20c A 392 C.s20c.02
Hydrophobic C-term T 360 - s20c A 392 C.s20c.02
Van-der-waals C-term T 360 - s20c A 392 C.s20c.02
Polar C-term C 358 - s20c D 405 C.s20c.15
Van-der-waals C-term C 358 - s20c D 405 C.s20c.15
Hydrophobic C-term T 360 - S20 D 390 C.S20.05
Van-der-waals C-term T 360 - S20 D 390 C.S20.05