Beta-arrestin-1 - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
VPAC2 75.2
Beta-arrestin-1 78.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 231 3x58 S6 F 75 N.S6.01
Hydrophobic TM3 L 231 3x58 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 L 231 3x58 s15s16 F 244 C.s15s16.03
Polar TM3 A 233 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 A 233 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 A 233 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 L 336 6x48 s5s6 V 70 N.s5s6.07
Ionic H8 R 388 8x56 s20c D 402 C.s20c.12
Polar H8 R 388 8x56 s20c D 402 C.s20c.12
Van-der-waals H8 R 388 8x56 s20c D 402 C.s20c.12
Polar TM3 L 230 3x57 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 230 3x57 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 L 230 3x57 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 230 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 L 230 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 306 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 306 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 L 230 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 D 314 - S6 D 78 N.S6.04
Van-der-waals ICL3 D 314 - S6 D 78 N.S6.04
Polar TM6 S 329 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 329 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 329 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 306 5x61 S6 F 75 N.S6.01
Van-der-waals TM5 L 306 5x61 S6 F 75 N.S6.01
Hydrophobic TM6 S 329 6x41 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 S 329 6x41 s5s6 L 73 N.s5s6.10
Polar ICL2 M 234 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 M 234 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 M 234 - s15s16 T 246 C.s15s16.05
Polar H8 C 384 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 C 384 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 C 384 8x52 s20c E 405 C.s20c.15
Hydrophobic TM5 K 309 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 309 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM7 Y 375 7x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 375 7x57 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 234 - S5 Y 63 N.S5.12
Polar TM2 R 158 2x46 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 R 158 2x46 s5s6 E 66 N.s5s6.03
Polar ICL2 M 234 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 M 234 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 M 234 - s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 306 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 306 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 310 5x65 s5s6 L 73 N.s5s6.10
Ionic TM2 R 158 2x46 s5s6 D 67 N.s5s6.04
Polar TM2 R 158 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 158 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 158 2x46 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 158 2x46 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 234 - S15 I 241 C.S15.14
Van-der-waals ICL2 M 234 - S15 I 241 C.S15.14
Hydrophobic TM6 L 333 6x45 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 333 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic H8 E 381 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 M 234 - s5s6 R 65 N.s5s6.02
Polar H8 S 380 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 V 232 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 232 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 227 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 L 231 3x58 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 231 3x58 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 K 153 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 K 153 12x49 s8s9 T 136 N.s8s9.07
Polar H8 E 381 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 L 227 3x54 s5s6 L 68 N.s5s6.05
Aromatic TM5 K 309 5x64 S6 F 75 N.S6.01
Hydrophobic TM5 K 309 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 K 309 5x64 S6 F 75 N.S6.01
Ionic ICL3 D 314 - S6 K 77 N.S6.03
Hydrophobic ICL3 D 314 - S6 K 77 N.S6.03
Van-der-waals ICL3 D 314 - S6 K 77 N.S6.03
Van-der-waals ICL3 S 312 - S6 K 77 N.S6.03
Hydrophobic ICL2 M 234 - S16 A 247 C.S16.01
Van-der-waals ICL2 M 234 - S16 A 247 C.S16.01