S-arrestin - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
VPAC2 74.2
S-arrestin 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 E 381 8x49 s5s6 D 75 N.s5s6.04
Polar ICL3 S 312 - S6 R 85 N.S6.03
Hydrophobic ICL3 S 312 - S6 R 85 N.S6.03
Van-der-waals ICL3 S 312 - S6 R 85 N.S6.03
Hydrophobic ICL2 M 234 - S16 D 257 C.S16.01
Van-der-waals ICL2 M 234 - S16 D 257 C.S16.01
Hydrophobic TM3 L 227 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 L 227 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 M 234 - S16 Y 259 C.S16.03
Van-der-waals ICL2 M 234 - S16 Y 259 C.S16.03
Polar H8 S 380 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 380 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 380 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals ICL2 M 234 - s8s9 K 145 N.s8s9.09
Polar TM3 A 233 3x60 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 A 233 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 306 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 306 5x61 s5s6 L 81 N.s5s6.10
Ionic TM6 K 324 6x36 s9s10 E 164 N.s9s10.06
Hydrophobic TM3 L 231 3x58 S6 F 83 N.S6.01
Hydrophobic TM6 S 329 6x41 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 329 6x41 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 332 6x44 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 332 6x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 333 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 D 314 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 D 314 - s17s18 V 324 C.s17s18.40
Hydrophobic TM4 P 237 4x39 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 P 237 4x39 s8s9 D 142 N.s8s9.06
Ionic TM6 R 325 6x37 s9s10 E 165 N.s9s10.07
Polar TM6 R 325 6x37 s9s10 E 165 N.s9s10.07
Polar TM2 R 158 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 158 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic TM7 Y 375 7x57 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 R 158 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 158 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 M 234 - S16 Y 258 C.S16.02
Van-der-waals ICL2 M 234 - S16 Y 258 C.S16.02
Hydrophobic TM6 S 329 6x41 s5s6 I 79 N.s5s6.08
Aromatic TM5 K 309 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 K 309 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 K 309 5x64 S6 F 83 N.S6.01
Hydrophobic ICL3 V 315 - S6 L 87 N.S6.05
Polar TM5 K 309 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 309 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 309 5x64 s15s16 Y 254 C.s15s16.03
Polar TM4 R 238 4x40 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 R 238 4x40 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 238 4x40 s8s9 Q 141 N.s8s9.05
Hydrophobic TM5 L 306 5x61 S6 F 83 N.S6.01
Van-der-waals TM5 L 306 5x61 S6 F 83 N.S6.01
Hydrophobic ICL3 V 315 - S6 D 86 N.S6.04
Van-der-waals ICL3 V 315 - S6 D 86 N.S6.04
Hydrophobic TM7 Y 375 7x57 s5s6 V 78 N.s5s6.07