Gs - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
VPAC2 78.9
Gαs 86.5
Gβ1 92.9
Gγ2 82.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 8.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 306 5x61 G.H5 L 388 G.H5.20
Aromatic TM2 R 158 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 158 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 158 2x46 G.H5 Y 391 G.H5.23
Polar TM5 K 309 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 309 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 309 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 332 6x44 G.H5 E 392 G.H5.24
Polar C-term E 434 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term E 434 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term E 434 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 336 6x48 G.H5 Y 391 G.H5.23
Ionic TM5 K 309 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 309 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 309 5x64 G.H5 D 381 G.H5.13
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 235 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 L 235 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM3 L 227 3x54 G.H5 L 393 G.H5.25
Hydrophobic H8 N 379 8x47 G.H5 E 392 G.H5.24
Polar C-term S 436 - G.H5 Q 390 G.H5.22
Van-der-waals C-term S 436 - G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 332 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 235 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 235 - G.S3 V 217 G.S3.01
Polar H8 S 380 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 380 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 380 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 K 309 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 M 234 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 234 - G.H5 F 376 G.H5.08
Hydrophobic TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 306 5x61 G.H5 L 394 G.H5.26
Polar TM4 R 238 4x40 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 238 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 238 4x40 G.HN Q 35 G.HN.52
Polar C-term I 438 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term I 438 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term I 438 - G.hns1 R 38 G.hns1.02
Polar TM6 R 325 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 325 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 325 6x37 G.H5 L 394 G.H5.26
Polar C-term V 437 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term V 437 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term V 437 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 306 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL3 V 315 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 M 234 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 234 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 235 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 L 235 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term L 431 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term L 431 - G.h4s6 R 356 G.h4s6.12
Polar TM6 S 329 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 329 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 329 6x41 G.H5 L 393 G.H5.25
Polar ICL3 S 312 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 312 - G.H5 R 385 G.H5.17
Hydrophobic TM6 L 333 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 333 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 234 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 234 - G.H5 I 383 G.H5.15
Hydrophobic TM5 L 310 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 310 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 M 234 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 M 234 - G.S3 V 217 G.S3.01
Polar TM5 K 309 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 309 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 309 5x64 G.H5 Q 384 G.H5.16
Polar C-term E 434 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term E 434 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term E 434 - G.h3s5 T 284 G.h3s5.02
Polar TM2 R 158 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 158 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 158 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 H 162 2x50 G.H5 Y 391 G.H5.23
Polar ICL2 M 234 - G.S1 H 41 G.S1.02
Hydrophobic TM4 R 238 4x40 G.HN K 34 G.HN.51
Hydrophobic ICL3 V 315 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 315 - G.H5 R 385 G.H5.17
Hydrophobic TM4 P 236 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 M 234 - G.S3 F 219 G.S3.03
Hydrophobic TM4 P 236 4x38 G.hns1 A 39 G.hns1.03
Van-der-waals TM4 P 236 4x38 G.hns1 A 39 G.hns1.03
Polar TM4 R 238 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM4 R 238 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 238 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 238 4x40 G.HN V 36 G.HN.53
Ionic ICL3 D 314 - G.H5 R 385 G.H5.17
Polar ICL3 D 314 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 M 234 - G.H5 C 379 G.H5.11
Van-der-waals TM6 L 332 6x44 G.H5 Y 391 G.H5.23
Hydrophobic TM7 Y 375 7x57 G.H5 Y 391 G.H5.23
Polar C-term I 438 - G.HN K 34 G.HN.51
Polar C-term Q 432 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term Q 432 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term Q 432 - G.H3 W 281 G.H3.17
Van-der-waals C-term Q 432 - G.H3 W 281 G.H3.17
Hydrophobic C-term S 429 - G.H3 R 280 G.H3.16
Van-der-waals C-term S 429 - G.H3 R 280 G.H3.16
Polar C-term S 429 - G.H3 R 280 G.H3.16
Ionic C-term E 434 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term E 434 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 434 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 434 - G.h4s6 R 356 G.h4s6.12
Ionic C-term E 434 - G.H5 R 389 G.H5.21
Polar C-term E 434 - G.H5 R 389 G.H5.21
Hydrophobic C-term E 434 - G.H5 R 389 G.H5.21
Van-der-waals C-term E 434 - G.H5 R 389 G.H5.21
Hydrophobic C-term I 438 - G.H5 Q 390 G.H5.22
Van-der-waals C-term I 438 - G.H5 Q 390 G.H5.22
Hydrophobic C-term R 426 - G.H2 R 232 G.H2.05
Van-der-waals C-term R 426 - G.H2 R 232 G.H2.05
Polar C-term S 429 - G.h4s6 R 356 G.h4s6.12
Polar C-term S 436 - G.HN Q 31 G.HN.48
Hydrophobic C-term S 436 - G.HN Q 31 G.HN.48
Van-der-waals C-term S 436 - G.HN Q 31 G.HN.48
Polar C-term Q 432 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term Q 432 - G.hns1 R 38 G.hns1.02
Polar C-term R 426 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term R 426 - G.h4s6 R 356 G.h4s6.12
Polar C-term G 424 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term G 424 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term F 430 - G.H5 M 386 G.H5.18
Hydrophobic C-term F 430 - G.H5 Q 390 G.H5.22
Van-der-waals C-term F 430 - G.H5 Q 390 G.H5.22
Polar C-term Q 428 - G.H5 R 389 G.H5.21
Hydrophobic C-term Q 428 - G.H5 R 389 G.H5.21
Van-der-waals C-term Q 428 - G.H5 R 389 G.H5.21
Ionic C-term E 434 - G.HN K 34 G.HN.51
Polar C-term E 434 - G.HN K 34 G.HN.51
Hydrophobic C-term E 434 - G.HN K 34 G.HN.51
Van-der-waals C-term E 434 - G.HN K 34 G.HN.51
Hydrophobic C-term Q 428 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term Q 428 - G.h3s5 T 284 G.h3s5.02
Polar C-term E 434 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term E 434 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term E 434 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term T 433 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term T 433 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term I 438 - G.H5 M 386 G.H5.18
Van-der-waals C-term I 438 - G.H5 M 386 G.H5.18
Hydrophobic C-term I 438 - G.H5 H 387 G.H5.19
Van-der-waals C-term I 438 - G.H5 H 387 G.H5.19