Arrestin-C - XCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
XCR1 78.0
Arrestin-C 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term Y 327 - s17s18 R 282 C.s17s18.11
Aromatic C-term Y 327 - s17s18 R 282 C.s17s18.11
Hydrophobic C-term Y 327 - s17s18 R 282 C.s17s18.11
Van-der-waals C-term Y 327 - s17s18 R 282 C.s17s18.11
Hydrophobic C-term Y 327 - s8s9 P 130 N.s8s9.04
Van-der-waals C-term Y 327 - s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 P 134 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 134 34x50 S6 F 71 N.S6.01
Hydrophobic TM6 L 226 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic C-term F 332 - s8s9 P 136 N.s8s9.10
Van-der-waals C-term F 332 - s8s9 P 136 N.s8s9.10
Polar TM3 S 130 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 S 130 3x53 s5s6 R 61 N.s5s6.02
Ionic H8 K 293 8x49 s5s6 D 62 N.s5s6.03
Polar H8 K 293 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 293 8x49 s5s6 D 62 N.s5s6.03
Polar TM3 S 130 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 S 130 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 S 130 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic H8 K 293 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 293 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 L 138 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 138 34x54 s15s16 Y 241 C.s15s16.03
Polar C-term F 332 - S5 R 58 N.S5.11
Hydrophobic C-term F 332 - S5 R 58 N.S5.11
Van-der-waals C-term F 332 - S5 R 58 N.S5.11
Hydrophobic ICL2 L 138 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 138 34x54 s15s16 S 242 C.s15s16.04
Ionic TM3 H 126 3x49 s5s6 D 63 N.s5s6.04
Polar TM3 H 126 3x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 H 126 3x49 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 H 126 3x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 V 131 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic C-term F 332 - S9 C 137 N.S9.01
Polar ICL1 E 63 12x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL1 E 63 12x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 E 63 12x51 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 R 127 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 V 131 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 131 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 138 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 138 34x54 S5 Y 59 N.S5.12
Hydrophobic TM3 V 131 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM7 Y 287 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 287 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 V 140 34x56 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 V 140 34x56 s8s9 A 133 N.s8s9.07
Polar ICL2 L 138 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 138 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 138 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 138 34x54 S16 D 244 C.S16.01
Polar TM2 S 64 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic H8 G 291 8x47 s5s6 V 66 N.s5s6.07
Polar TM6 T 223 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 T 223 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 223 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic C-term Y 333 - S10 V 164 N.S10.05
Van-der-waals C-term Y 333 - S10 V 164 N.S10.05
Polar TM2 S 64 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 S 64 2x37 s5s6 D 62 N.s5s6.03
Polar TM2 T 66 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 66 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 66 2x39 s5s6 D 63 N.s5s6.04
Polar TM6 T 223 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 223 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 223 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic C-term F 332 - S5 Y 59 N.S5.12
Hydrophobic TM3 S 130 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 T 137 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 T 137 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 T 137 34x53 s5s6 R 61 N.s5s6.02
Polar TM6 K 218 6x28 S10 Y 160 N.S10.01
Hydrophobic TM6 K 218 6x28 S10 Y 160 N.S10.01
Van-der-waals TM6 K 218 6x28 S10 Y 160 N.S10.01
Hydrophobic TM5 L 212 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 212 5x65 s5s6 L 69 N.s5s6.10
Polar ICL2 V 140 34x56 S16 D 244 C.S16.01
Hydrophobic ICL2 V 140 34x56 S16 D 244 C.S16.01
Hydrophobic ICL2 P 134 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 134 34x50 s15s16 Y 241 C.s15s16.03
Aromatic C-term Y 333 - S5 R 58 N.S5.11
Aromatic C-term Y 333 - s17s18 K 289 C.s17s18.18
Hydrophobic C-term Y 333 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term Y 333 - s17s18 K 289 C.s17s18.18
Hydrophobic TM2 T 66 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals C-term Y 333 - S10 R 162 N.S10.03
Ionic ICL3 R 216 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 216 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 216 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term F 332 - s5s6 G 60 N.s5s6.01
Van-der-waals C-term F 332 - s5s6 G 60 N.s5s6.01
Polar TM6 T 223 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 135 34x51 s15s16 L 240 C.s15s16.02
Hydrophobic ICL2 L 135 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 135 34x51 s15s16 Y 241 C.s15s16.03
Ionic H8 K 299 8x55 s20c E 383 C.s20c.17
Polar H8 K 299 8x55 s20c E 383 C.s20c.17
Van-der-waals H8 K 299 8x55 s20c E 383 C.s20c.17
Polar C-term Y 333 - S9 D 140 N.S9.04