Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

10KT

SPECIES

Homo sapiens

RESOLUTION

2.590

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Compound 50 I66 2.64x63 TM2 hydrophobic
Compound 50 F168 45.52x52 ECL2 aromatic (face-to-face)
Compound 50 E169 ECL2 polar (charge-assisted hydrogen bond)
Compound 50 M177 5.38x40 TM5 Van der Waals
Compound 50 M177 5.38x40 TM5 hydrophobic
Compound 50 L249 6.51x51 TM6 hydrophobic
Compound 50 L249 6.51x51 TM6 Van der Waals
Compound 50 N253 6.55x55 TM6 polar (hydrogen bond)
Compound 50 N253 6.55x55 TM6 polar (hydrogen bond)
Compound 50 H264 ECL3 Van der Waals
Compound 50 L267 7.32x31 TM7 hydrophobic
Compound 50 L267 7.32x31 TM7 Van der Waals
Compound 50 Y271 7.36x35 TM7 hydrophobic
Compound 50 Y271 7.36x35 TM7 Van der Waals
Compound 50 I274 7.39x38 TM7 Van der Waals
Compound 50 I274 7.39x38 TM7 hydrophobic

Ligands

Compound 50

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x63 2.64x63 I66
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x35 7.36x35 Y271
7x38 7.39x38 I274