Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

12IZ

SPECIES

Homo sapiens

RESOLUTION

2.720

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 15, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
'5249 F87 2.57x57 TM2 hydrophobic
'5249 F91 2.61x61 TM2 hydrophobic
'5249 F94 2.64x64 TM2 aromatic (face-to-edge)
'5249 H95 2.65x65 TM2 Van der Waals
'5249 H95 2.65x65 TM2 polar (hydrogen bond)
'5249 I110 3.29x29 TM3 hydrophobic
'5249 I110 3.29x29 TM3 Van der Waals
'5249 V113 3.32x32 TM3 hydrophobic
'5249 V113 3.32x32 TM3 Van der Waals
'5249 T114 3.33x33 TM3 polar (hydrogen bond)
'5249 F117 3.36x36 TM3 Van der Waals
'5249 F117 3.36x36 TM3 hydrophobic
'5249 F183 ECL2 Van der Waals
'5249 F183 ECL2 aromatic (face-to-edge)
'5249 Y190 5.39x39 TM5 Van der Waals
'5249 W194 5.43x43 TM5 hydrophobic
'5249 W194 5.43x43 TM5 Van der Waals
'5249 F281 7.35x34 TM7 hydrophobic
'5249 F281 7.35x34 TM7 Van der Waals
'5249 C288 7.42x41 TM7 Van der Waals

Ligands

'5249

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
2x65 2.65x65 H95
TM3
3x29 3.29x29 I110
3x32 3.32x32 V113
3x33 3.33x33 T114
3x36 3.36x36 F117
TM5
5x39 5.39x39 Y190
5x43 5.43x43 W194
TM7
7x34 7.35x34 F281
7x41 7.42x41 C288