Structure information

CRF1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

4K5Y

SPECIES

Homo sapiens

RESOLUTION

2.980

PREFERRED CHAIN

B

REFERENCE

10.1038/NATURE12357

PUBLICATION DATE

July 17, 2013

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CP 376,395 F203 3.44x44 TM3 hydrophobic
CP 376,395 M206 3.47x47 TM3 hydrophobic
CP 376,395 L280 5.47x47 TM5 hydrophobic
CP 376,395 N283 5.50x50 TM5 Van der Waals
CP 376,395 N283 5.50x50 TM5 polar (hydrogen bond)
CP 376,395 F284 5.51x51 TM5 hydrophobic
CP 376,395 L287 5.54x54 TM5 hydrophobic
CP 376,395 L287 5.54x54 TM5 Van der Waals
CP 376,395 T316 6.42x42 TM6 Van der Waals
CP 376,395 L319 6.45x45 TM6 hydrophobic
CP 376,395 L320 6.46x46 TM6 hydrophobic
CP 376,395 L320 6.46x46 TM6 Van der Waals
CP 376,395 L323 6.49x49 TM6 hydrophobic
CP 376,395 L323 6.49x49 TM6 Van der Waals
CP 376,395 Y327 6.53x53 TM6 Van der Waals
CP 376,395 Y327 6.53x53 TM6 hydrophobic

Ligands

CP 376,395

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Residue Diagrams

L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM3
3x40 3.44x44 F203
3x43 3.47x47 M206
TM5
5x51 5.47x47 L280
5x54 5.50x50 N283
5x55 5.51x51 F284
5x58 5.54x54 L287
TM6
6x37 6.42x42 T316
6x40 6.45x45 L319
6x41 6.46x46 L320
6x44 6.49x49 L323
6x48 6.53x53 Y327