Structure information

M3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZHP

SPECIES

Rattus norvegicus

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.1813988115

PUBLICATION DATE

Nov. 28, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
6o (BS46) Y148 3.33x33 TM3 hydrophobic
6o (BS46) S151 3.36x36 TM3 polar (hydrogen bond)
6o (BS46) S151 3.36x36 TM3 Van der Waals
6o (BS46) N152 3.37x37 TM3 Van der Waals
6o (BS46) W199 4.57x57 TM4 hydrophobic
6o (BS46) W199 4.57x57 TM4 Van der Waals
6o (BS46) L225 ECL2 Van der Waals
6o (BS46) T231 5.39x40 TM5 Van der Waals
6o (BS46) T234 5.42x43 TM5 Van der Waals
6o (BS46) A235 5.43x44 TM5 Van der Waals
6o (BS46) A235 5.43x44 TM5 hydrophobic
6o (BS46) A238 5.46x461 TM5 Van der Waals
6o (BS46) A238 5.46x461 TM5 hydrophobic
6o (BS46) W503 6.48x48 TM6 hydrophobic
6o (BS46) W503 6.48x48 TM6 Van der Waals
6o (BS46) Y506 6.51x51 TM6 hydrophobic
6o (BS46) Y506 6.51x51 TM6 Van der Waals
6o (BS46) N507 6.52x52 TM6 Van der Waals
6o (BS46) N507 6.52x52 TM6 polar (hydrogen bond)
6o (BS46) N507 6.52x52 TM6 polar (hydrogen bond)
6o (BS46) Y529 7.39x38 TM7 hydrophobic
6o (BS46) Y529 7.39x38 TM7 Van der Waals
6o (BS46) C532 7.42x41 TM7 Van der Waals
6o (BS46) C532 7.42x41 TM7 hydrophobic

Ligands

6o (BS46)

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Residue Diagrams

I N G I I T V L A L F G T L F A I F V V 1 L S L A C A D L I I G I V S M N L F T T Y 2 V L L N M V S A N S A V Y D I S L W L D 3 A G V M I G L A W V I S F V L W A P A I 4 Y L I T M I T V P M Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 V P N V T S N I Y C L W Y G L N W Y T 7
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ICL1 K Q L K ICL1ECL1 N R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P P G E C F I Q F L S ECL2ICL3 Q A S G T E A E A E N F V H P T G S S R S C S S Y E L Q Q Q G V K R S S R R K Y G R C H F W F T T K S W K P S A E Q M D Q D H S S S D S W N N N D A A A S L E N S A S S D E E D I G S E T R A I Y S I V L K L P G H S S I L N S T K L P S S D N L Q V S N E D L G T V D V E R N A H K L Q A Q K S M G D G D N C Q K D F T K L P I Q L E S A V D T G K T S D T N S S A D K T T A T L P L S F K E A T L A K R F A L K T R S Q I T K R K ICL3ECL3 D S C I ECL3N-term M T L H S N S T T S P L F P N I S S S W V H S P S E A G L P L G T V T Q L G S Y N I S Q E T G N F S S N D T S S D P L G G H N-termC-term Q C D K R K R R K Q Q Y Q Q R Q S V I F H K R V P E Q A L C-term T I W Q V V F I A F L T G F L A L V T I I G N I L V I V A F K V N T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M G N L A C D L W L S I D Y V A S N A S V M N L L V I S F D R Y F S I T R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L A G L R M S L I K E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C P K T Y W N L G Y W L C Y I N S T V N P V C Y A L C N K T F K T F R T T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M3 receptor
TM3
3x33 3.33x33 Y148
3x36 3.36x36 S151
3x37 3.37x37 N152
TM4
4x57 4.57x57 W199
TM5
5x40 5.39x40 T231
5x43 5.42x43 T234
5x44 5.43x44 A235
5x461 5.46x461 A238
TM6
6x48 6.48x48 W503
6x51 6.51x51 Y506
6x52 6.52x52 N507
TM7
7x38 7.39x38 Y529
7x41 7.42x41 C532