Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

6XBM

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-020-0646-2

PUBLICATION DATE

Sept. 30, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
24(S),25-Epoxycholesterol N219 N-term Van der Waals
24(S),25-Epoxycholesterol N219 N-term polar (hydrogen bond)
24(S),25-Epoxycholesterol F222 N-term hydrophobic
24(S),25-Epoxycholesterol F222 N-term Van der Waals
24(S),25-Epoxycholesterol L325 3.36x36 TM3 hydrophobic
24(S),25-Epoxycholesterol L325 3.36x36 TM3 Van der Waals
24(S),25-Epoxycholesterol D384 ECL2 Van der Waals
24(S),25-Epoxycholesterol V386 ECL2 Van der Waals
24(S),25-Epoxycholesterol F391 45.51x51 ECL2 hydrophobic
24(S),25-Epoxycholesterol F391 45.51x51 ECL2 Van der Waals
24(S),25-Epoxycholesterol Y394 ECL2 hydrophobic
24(S),25-Epoxycholesterol Y394 ECL2 Van der Waals
24(S),25-Epoxycholesterol R400 5.43x44 TM5 Van der Waals
24(S),25-Epoxycholesterol T466 6.47x47 TM6 Van der Waals
24(S),25-Epoxycholesterol H470 6.51x51 TM6 Van der Waals
24(S),25-Epoxycholesterol E518 7.38x38 TM7 Van der Waals
24(S),25-Epoxycholesterol N521 7.41x41 TM7 Van der Waals
24(S),25-Epoxycholesterol M525 7.45x45 TM7 Van der Waals
24(S),25-Epoxycholesterol M525 7.45x45 TM7 hydrophobic

Ligands

24(S),25-Epoxycholesterol

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R L G E P T S N E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K Q P I P D C E I K N R P ECL3N-term M A A A R P A R G P E L P L L G L L L L L L L G D P G R G A A S S G N A T G P G P R S A G G S A R R S A A V T G P P P P L S H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G Q S D D E P K R I K K S K M I A K A F S K R H E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D I S V T P V A T P V P P E E Q A N L W L V E A E I S P E L Q K R L G R K K K R R K R K K E V C P L A P P P E L H P P A P A P S T I P R L P Q L P R Q K C L V A A G A W G A G D S C R Q G A W T L V S N P F C P E P S P P Q D P F L P S A P A P V A W A H G R R Q G L G P I H S R T N L M D T E L M D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM3
3x36 3.36x36 L325
ECL2
45x51 45.51x51 F391
TM5
5x40 5.43x44 R400
TM6
6x51 6.47x47 T466
6x55 6.51x51 H470
TM7
7x35 7.38x38 E518
7x38 7.41x41 N521
7x42 7.45x45 M525