Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7INB

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S42004-026-02059-7

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
4-methoxybenzamide N42 2.40x40 TM2 polar (hydrogen bond)
4-methoxybenzamide V45 2.43x43 TM2 Van der Waals
4-methoxybenzamide V45 2.43x43 TM2 hydrophobic
4-methoxybenzamide I98 3.46x46 TM3 hydrophobic
4-methoxybenzamide I98 3.46x46 TM3 Van der Waals
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
4-methoxybenzamide A231 6.33x33 TM6 Van der Waals
4-methoxybenzamide A235 6.37x37 TM6 Van der Waals
4-methoxybenzamide A235 6.37x37 TM6 hydrophobic
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline M270 7.35x34 TM7 Van der Waals
theophylline I274 7.39x38 TM7 Van der Waals
theophylline I274 7.39x38 TM7 hydrophobic
4-methoxybenzamide Y288 7.53x53 TM7 hydrophobic
4-methoxybenzamide Y288 7.53x53 TM7 Van der Waals
4-methoxybenzamide I292 8.47x47 H8 Van der Waals
4-methoxybenzamide I292 8.47x47 H8 hydrophobic

Ligands

4-methoxybenzamide

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theophylline

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x40 2.40x40 N42
2x43 2.43x43 V45
TM3
3x46 3.46x46 I98
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
7x53 7.53x53 Y288
H8
8x47 8.47x47 I292