Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7INF

SPECIES

Homo sapiens

RESOLUTION

2.260

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2,4-difluorobenzene-1-carbothioamide N42 2.40x40 TM2 polar (hydrogen bond)
2,4-difluorobenzene-1-carbothioamide N42 2.40x40 TM2 polar (hydrogen bond)
2,4-difluorobenzene-1-carbothioamide V45 2.43x43 TM2 Van der Waals
2,4-difluorobenzene-1-carbothioamide V45 2.43x43 TM2 hydrophobic
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
2,4-difluorobenzene-1-carbothioamide A231 6.33x33 TM6 Van der Waals
2,4-difluorobenzene-1-carbothioamide A235 6.37x37 TM6 Van der Waals
2,4-difluorobenzene-1-carbothioamide A235 6.37x37 TM6 hydrophobic
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline I274 7.39x38 TM7 Van der Waals
theophylline I274 7.39x38 TM7 hydrophobic
2,4-difluorobenzene-1-carbothioamide Y288 7.53x53 TM7 Van der Waals
2,4-difluorobenzene-1-carbothioamide Y288 7.53x53 TM7 hydrophobic
2,4-difluorobenzene-1-carbothioamide I292 8.47x47 H8 hydrophobic
2,4-difluorobenzene-1-carbothioamide I292 8.47x47 H8 Van der Waals

Ligands

2,4-difluorobenzene-1-carbothioamide

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theophylline

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x40 2.40x40 N42
2x43 2.43x43 V45
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274
7x53 7.53x53 Y288
H8
8x47 8.47x47 I292