Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7IOU

SPECIES

Homo sapiens

RESOLUTION

2.170

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FU163-75 N36 12.49x49 ICL1 polar (hydrogen bond with backbone)
FU163-75 N36 12.49x49 ICL1 Van der Waals
FU163-75 L37 12.50x50 ICL1 Van der Waals
FU163-75 N39 2.37x37 TM2 Van der Waals
FU163-75 N39 2.37x37 TM2 polar (hydrogen bond)
FU163-75 N42 2.40x40 TM2 polar (hydrogen bond)
FU163-75 N42 2.40x40 TM2 polar (hydrogen bond)
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
FU163-75 A231 6.33x33 TM6 hydrophobic
FU163-75 A231 6.33x33 TM6 Van der Waals
FU163-75 A235 6.37x37 TM6 hydrophobic
FU163-75 A235 6.37x37 TM6 Van der Waals
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline M270 7.35x34 TM7 Van der Waals
theophylline I274 7.39x38 TM7 Van der Waals
theophylline I274 7.39x38 TM7 hydrophobic
FU163-75 I292 8.47x47 H8 Van der Waals
FU163-75 I292 8.47x47 H8 hydrophobic

Ligands

FU163-75

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theophylline

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ICL1
12x49 12.49x49 N36
12x50 12.50x50 L37
TM2
2x37 2.37x37 N39
2x40 2.40x40 N42
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
H8
8x47 8.47x47 I292