Structure information

TSH receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T9I

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-022-05159-1

PUBLICATION DATE

Aug. 3, 2022

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Thyrotropin subunit beta (TSH subunit beta) K42 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) K58 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I60 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I60 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) E61 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R80 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) Y82 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) Y82 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) S84 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I85 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) I85 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) V87 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) H105 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) R109 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R109 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R109 N-term polar (charge-charge)
Glycoprotein hormones alpha chain (TSH subunit alpha) N110 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) N110 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) R112 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) K129 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F130 N-term aromatic (face-to-edge)
Glycoprotein hormones alpha chain (TSH subunit alpha) F130 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F134 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) N135 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) N135 N-term polar (hydrogen bond with backbone)
Glycoprotein hormones alpha chain (TSH subunit alpha) T136 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) G137 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) I152 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I152 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) F153 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) F153 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F153 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) F153 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I155 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) I155 N-term hydrophobic
Glycoprotein hormones alpha chain (TSH subunit alpha) E157 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) D160 N-term polar (hydrogen bond with backbone)
Glycoprotein hormones alpha chain (TSH subunit alpha) D160 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) P162 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) Y163 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) K183 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) Y185 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) Y185 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (hydrogen bond with backbone)
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (charge-charge)
Thyrotropin subunit beta (TSH subunit beta) A204 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) A204 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) Y206 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) N208 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) K209 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) K209 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) S229 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) L230 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) L230 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) E251 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) I253 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) R255 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) R274 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) D276 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) G294 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) L296 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) L296 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) E297 N-term polar (hydrogen bond with backbone)
Thyrotropin subunit beta (TSH subunit beta) E297 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) F381 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) D382 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) Y385 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) T388 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I389 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) I389 N-term Van der Waals

Ligands

Thyrotropin subunit beta (TSH subunit beta)

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Glycoprotein hormones alpha chain (TSH subunit alpha)

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

V N G L L A L L S V F W V V I R L F K Y 1 C N L A F A D F C M G M Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T N 3 A C A I M V G G W V C C F L L A L L P L 4 Y C C C V I V F A V I N L T L V F V I Y 5 A V L I F T D F I C M A P I S F Y A L S 6 F P N A C S N L P Y F L V L L I K S N 7
Download: PNG | SVG
ICL1 H Y K L N ICL1ECL1 H S E Y Y N H A I D W Q T ECL1ICL2 A M R L D R K I ICL2ECL2 I S S Y A K V S I C L P M D T E ECL2ICL3 P Q Y N ICL3ECL3 K P L I T ECL3N-term M R P A D L L Q L V L L L D L P R D L G G M G C S S P P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P S H C C A F K N Q K K I R G I L E S L M C N E S S M Q S L R Q R K S V N A L N S P L H Q E Y E E N L G D S I V G Y K E K S K F Q D T H N N A H Y Y V F F E E Q E D E I I G F G Q E L K N P Q E E T L Q A F D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G N-termC-term G I C K R Q A Q A Y R G Q R V P P K N S T D I Q V Q K V T H D M R Q G L H N M E D V Y E L I E N S H L T P K K Q G Q I S E E Y M Q T V L C-term Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F R L R H A C A I M V G G W V C C F L L A L L P L V G T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N P G D K D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A V F I F F Q R D L L S K
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
TSH receptor