Structure information

GPR183

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TUY

SPECIES

Homo sapiens

RESOLUTION

2.980

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2022.04.006

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GSK682753A M34 1.35x35 TM1 hydrophobic
GSK682753A Y38 1.39x39 TM1 hydrophobic
GSK682753A R87 2.60x60 TM2 polar (charge-assisted hydrogen bond)
GSK682753A Y90 ECL1 hydrophobic
GSK682753A Y90 ECL1 Van der Waals
GSK682753A F111 3.32x32 TM3 hydrophobic
GSK682753A F111 3.32x32 TM3 Van der Waals
GSK682753A Y112 3.33x33 TM3 Van der Waals
GSK682753A Y184 ECL2 hydrophobic
GSK682753A Y184 ECL2 Van der Waals
GSK682753A L197 5.39x40 TM5 Van der Waals
GSK682753A L197 5.39x40 TM5 hydrophobic
GSK682753A Y250 6.51x51 TM6 hydrophobic
GSK682753A Y250 6.51x51 TM6 Van der Waals
GSK682753A I254 6.55x55 TM6 hydrophobic
GSK682753A I254 6.55x55 TM6 Van der Waals
GSK682753A V284 7.39x38 TM7 hydrophobic
GSK682753A V284 7.39x38 TM7 Van der Waals

Ligands

GSK682753A

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Residue Diagrams

L N G V L G I I F V L S Y H L P M V I R 1 T N L V I S D I L F T T A L P T R I A Y 2 C T M F N V G A Y T N I Y F V L A T I R 3 A K G V C I F V W I L V F A Q T L P L 4 Y C I L I I I L P L V Y G I F C A G L L I 5 I L I I V V F V L C F T P Y H V A I I Q 6 F P D M C C N F N M L C V T F H L S I 7
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ICL1 R K K I ICL1ECL1 F D W R I ECL1ICL2 P L R Y N K I K ICL2ECL2 M S K Q E A E R I T C M E Y P N F E E T K ECL2ICL3 P L T E K S ICL3ECL3 S N F L E C ECL3N-term M D I Q M A N N F T P P S A T P Q G N D C D L Y A N-termC-term Q V S V S I S S A V K S A P E E N S R E M T E T Q M M I H S K S S N G K C-term H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H R I E H A K G V C I F V W I L V F A Q T L P L L I N P S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G V M R Y K R K M L K R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR183
TM1
1x35 1.35x35 M34
1x39 1.39x39 Y38
TM2
2x60 2.60x60 R87
TM3
3x32 3.32x32 F111
3x33 3.33x33 Y112
TM5
5x40 5.39x40 L197
TM6
6x51 6.51x51 Y260
6x55 6.55x55 I264
TM7
7x38 7.39x38 V294