Structure information

GPR183

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TUZ

SPECIES

Homo sapiens

RESOLUTION

3.120

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2022.04.006

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
7α,25-dihydroxycholesterol Y112 3.33x33 TM3 polar (hydrogen bond)
7α,25-dihydroxycholesterol Y116 3.37x37 TM3 polar (hydrogen bond)
7α,25-dihydroxycholesterol Q162 4.56x56 TM4 Van der Waals
7α,25-dihydroxycholesterol Y184 ECL2 hydrophobic
7α,25-dihydroxycholesterol Y184 ECL2 Van der Waals
7α,25-dihydroxycholesterol L197 5.39x40 TM5 Van der Waals
7α,25-dihydroxycholesterol A200 5.42x43 TM5 hydrophobic
7α,25-dihydroxycholesterol A200 5.42x43 TM5 Van der Waals
7α,25-dihydroxycholesterol Y260 6.51x51 TM6 Van der Waals
7α,25-dihydroxycholesterol L290 7.35x34 TM7 hydrophobic
7α,25-dihydroxycholesterol V294 7.39x38 TM7 hydrophobic

Ligands

7α,25-dihydroxycholesterol

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Residue Diagrams

L N G V L G I I F V L S Y H L P M V I R 1 T N L V I S D I L F T T A L P T R I A Y 2 C T M F N V G A Y T N I Y F V L A T I R 3 A K G V C I F V W I L V F A Q T L P L 4 Y C I L I I I L P L V Y G I F C A G L L I 5 I L I I V V F V L C F T P Y H V A I I Q 6 F P D M C C N F N M L C V T F H L S I 7
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ICL1 R K K I ICL1ECL1 F D W R I ECL1ICL2 P L R Y N K I K ICL2ECL2 M S K Q E A E R I T C M E Y P N F E E T K ECL2ICL3 P L T E K S ICL3ECL3 S N F L E C ECL3N-term M D I Q M A N N F T P P S A T P Q G N D C D L Y A N-termC-term Q V S V S I S S A V K S A P E E N S R E M T E T Q M M I H S K S S N G K C-term H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H R I E H A K G V C I F V W I L V F A Q T L P L L I N P S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G V M R Y K R K M L K R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR183
TM3
3x33 3.33x33 Y112
3x37 3.37x37 Y116
TM4
4x56 4.56x56 Q162
TM5
5x40 5.39x40 L197
5x43 5.42x43 A200
TM6
6x51 6.51x51 Y260
TM7
7x34 7.35x34 L290
7x38 7.39x38 V294