Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7V6A

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-30595-Y

PUBLICATION DATE

May 11, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL6164470 F186 45.51x51 ECL2 hydrophobic
CHEMBL6164470 Y416 6.51x51 TM6 hydrophobic
CHEMBL6164470 V420 6.55x55 TM6 hydrophobic
CHEMBL6164470 Q427 ECL3 Van der Waals
CHEMBL6164470 Q427 ECL3 polar (hydrogen bond with backbone)
CHEMBL6164470 S428 ECL3 Van der Waals
CHEMBL6164470 C429 ECL3 Van der Waals
CHEMBL6164470 I430 ECL3 polar (hydrogen bond with backbone)
CHEMBL6164470 I430 ECL3 Van der Waals
CHEMBL6164470 D432 7.32x31 TM7 Van der Waals
CHEMBL6164470 W435 7.35x34 TM7 hydrophobic
CHEMBL6164470 W435 7.35x34 TM7 Van der Waals

Ligands

CHEMBL6164470

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
ECL2
45x51 45.51x51 F186
TM6
6x51 6.51x51 Y416
6x55 6.55x55 V420
TM7
7x31 7.32x31 D432
7x34 7.35x34 W435