Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W0O

SPECIES

Homo sapiens

RESOLUTION

3.780

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00797-5

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 aromatic (face-to-edge)
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) R168 ECL2 polar (charge-assisted hydrogen bond)
Elabela/Toddler-32 (Human) Q180 ECL2 Van der Waals
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 Van der Waals
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 polar (hydrogen bond with backbone)
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 hydrophobic
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 Van der Waals
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 polar (hydrogen bond with backbone)
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) M288 7.32x31 TM7 Van der Waals

Ligands

Elabela/Toddler-32 (Human)

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
TM7
7x31 7.32x31 M288