Structure information

α2A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W6P

SPECIES

Homo sapiens

RESOLUTION

3.470

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABN7065

PUBLICATION DATE

Sept. 28, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL5542553 V129 3.33x33 TM3 hydrophobic
CHEMBL5542553 I205 45.52x52 ECL2 hydrophobic
CHEMBL5542553 W402 6.48x48 TM6 aromatic (edge-to-face)
CHEMBL5542553 F405 6.51x51 TM6 aromatic (face-to-edge)
CHEMBL5542553 F406 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL5542553 Y409 6.55x55 TM6 hydrophobic
CHEMBL5542553 F427 7.39x38 TM7 aromatic (face-to-face)
CHEMBL5542553 F427 7.39x38 TM7 polar (hydrogen bond with backbone)
CHEMBL5542553 F427 7.39x38 TM7 Van der Waals
CHEMBL5542553 Y431 7.43x42 TM7 aromatic (face-to-edge)
CHEMBL5542553 Y431 7.43x42 TM7 Van der Waals

Ligands

CHEMBL5542553

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Residue Diagrams

V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x33 3.33x33 V129
ECL2
45x52 45.52x52 I205
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431