Structure information

RXFP4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YJ4

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-36182-Z

PUBLICATION DATE

March 1, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
INSL5 (chain B) W97 2.60x60 TM2 Van der Waals
INSL5 (chain B) W97 2.60x60 TM2 hydrophobic
INSL5 (chain B) E100 2.63x63 TM2 polar (charge-assisted hydrogen bond)
INSL5 (chain B) D104 ECL1 polar (charge-assisted hydrogen bond)
INSL5 (chain B) F105 ECL1 Van der Waals
INSL5 (chain B) F105 ECL1 aromatic (edge-to-face)
INSL5 (chain B) L118 3.29x29 TM3 Van der Waals
INSL5 (chain B) T121 3.32x32 TM3 polar (hydrogen bond)
INSL5 (chain B) T121 3.32x32 TM3 Van der Waals
INSL5 (chain B) C186 ECL2 Van der Waals
INSL5 (chain B) L190 ECL2 Van der Waals
INSL5 (chain B) Q205 5.39x40 TM5 Van der Waals
INSL5 (chain B) Q205 5.39x40 TM5 polar (hydrogen bond)
INSL5 (chain B) R208 5.42x43 TM5 polar (charge-assisted hydrogen bond)
INSL5 (chain A) V277 ECL3 Van der Waals
INSL5 (chain A) W279 ECL3 hydrophobic
INSL5 (chain A) W279 ECL3 Van der Waals
INSL5 (chain B) Q287 7.31x30 TM7 polar (hydrogen bond with backbone)
INSL5 (chain B) Q287 7.31x30 TM7 Van der Waals
INSL5 (chain B) T288 7.32x31 TM7 Van der Waals
INSL5 (chain B) F291 7.35x34 TM7 hydrophobic
INSL5 (chain B) F291 7.35x34 TM7 Van der Waals
INSL5 (chain B) H299 7.43x42 TM7 Van der Waals

Ligands

INSL5 (chain B)

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INSL5 (chain A)

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Residue Diagrams

L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7
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ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
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Residue Table


GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x60 2.60x60 W97
2x63 2.63x63 E100
TM3
3x29 3.29x29 L118
3x32 3.32x32 T121
TM5
5x40 5.39x40 Q205
5x43 5.42x43 R208
TM7
7x30 7.31x30 Q287
7x31 7.32x31 T288
7x34 7.35x34 F291
7x42 7.43x42 H299