Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

7ZI0

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABM5563

PUBLICATION DATE

June 15, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol D95 N-term polar (charge-assisted hydrogen bond)
Cholesterol K105 N-term Van der Waals
Cholesterol L108 N-term Van der Waals
Cholesterol L108 N-term hydrophobic
Cholesterol W109 N-term hydrophobic
Cholesterol W109 N-term Van der Waals
Cholesterol G111 N-term Van der Waals
Cholesterol L112 N-term hydrophobic
Cholesterol L112 N-term Van der Waals
Cholesterol I156 N-term hydrophobic
Cholesterol V157 N-term hydrophobic
Cholesterol V157 N-term Van der Waals
Cholesterol R161 N-term Van der Waals
Cholesterol P164 N-term hydrophobic
SAG1.3 I215 N-term hydrophobic
SAG1.3 N219 N-term polar (hydrogen bond)
SAG1.3 N219 N-term polar (hydrogen bond)
SAG1.3 L221 N-term Van der Waals
SAG1.3 L221 N-term hydrophobic
SAG1.3 M301 ECL1 hydrophobic
SAG1.3 M301 ECL1 Van der Waals
SAG1.3 L303 ECL1 Van der Waals
SAG1.3 L303 ECL1 hydrophobic
SAG1.3 D384 ECL2 Van der Waals
SAG1.3 Y394 ECL2 hydrophobic
SAG1.3 Y394 ECL2 Van der Waals
SAG1.3 K395 ECL2 Van der Waals
SAG1.3 D577 6.54x54 TM6 polar (charge-assisted hydrogen bond)
SAG1.3 Q581 6.58x58 TM6 Van der Waals
SAG1.3 W584 6.61x61 TM6 Van der Waals
SAG1.3 W584 6.61x61 TM6 hydrophobic
SAG1.3 E585 6.62x62 TM6 Van der Waals
SAG1.3 F588 6.65x65 TM6 Van der Waals
SAG1.3 F588 6.65x65 TM6 hydrophobic
Cholesterol L593 6.70x70 TM6 hydrophobic
Cholesterol A596 6.73x73 TM6 hydrophobic
Cholesterol I600 ECL3 Van der Waals
Cholesterol I600 ECL3 hydrophobic
SAG1.3 P617 ECL3 Van der Waals
SAG1.3 P617 ECL3 hydrophobic
SAG1.3 E622 7.38x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Cholesterol

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SAG1.3

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R L G E P T S N E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K Q P I P D C E I K N R P ECL3N-term M A A A R P A R G P E L P L L G L L L L L L L G D P G R G A A S S G N A T G P G P R S A G G S A R R S A A V T G P P P P L S H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G Q S D D E P K R I K K S K M I A K A F S K R H E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D I S V T P V A T P V P P E E Q A N L W L V E A E I S P E L Q K R L G R K K K R R K R K K E V C P L A P P P E L H P P A P A P S T I P R L P Q L P R Q K C L V A A G A W G A G D S C R Q G A W T L V S N P F C P E P S P P Q D P F L P S A P A P V A W A H G R R Q G L G P I H S R T N L M D T E L M D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM6
6x58 6.54x54 D473
6x62 6.58x58 Q477
6x65 6.61x61 W480
6x66 6.62x62 E481
6x69 6.65x65 F484
6x74 6.70x70 L489
6x77 6.73x73 A492
TM7
7x35 7.38x38 E518