Structure information

HCA2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H2G

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Oct. 11, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
nicotinic acid L83 2.60x60 TM2 hydrophobic
nicotinic acid Y87 2.64x64 TM2 Van der Waals
nicotinic acid Y87 2.64x64 TM2 polar (hydrogen bond)
nicotinic acid L107 3.32x32 TM3 Van der Waals
nicotinic acid L107 3.32x32 TM3 hydrophobic
nicotinic acid R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
nicotinic acid S178 45.51x51 ECL2 Van der Waals
nicotinic acid S179 45.52x52 ECL2 Van der Waals
nicotinic acid F180 ECL2 Van der Waals
nicotinic acid F180 ECL2 hydrophobic
nicotinic acid L280 7.39x38 TM7 hydrophobic
nicotinic acid L280 7.39x38 TM7 Van der Waals
nicotinic acid Y284 7.43x42 TM7 polar (hydrogen bond)

Ligands

nicotinic acid

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
2x64 2.64x64 Y87
TM3
3x32 3.32x32 L107
3x36 3.36x36 R111
ECL2
45x51 45.51x51 S178
45x52 45.52x52 S179
TM7
7x38 7.39x38 L280
7x42 7.43x42 Y284