Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8RW7

SPECIES

Homo sapiens

RESOLUTION

2.250

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Jan. 8, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3736368 F168 45.52x52 ECL2 aromatic (face-to-face)
CHEMBL3736368 M177 5.38x40 TM5 hydrophobic
CHEMBL3736368 L249 6.51x51 TM6 hydrophobic
CHEMBL3736368 N253 6.55x55 TM6 polar (hydrogen bond)
CHEMBL3736368 N253 6.55x55 TM6 Van der Waals
CHEMBL3736368 L267 7.32x31 TM7 Van der Waals
CHEMBL3736368 L267 7.32x31 TM7 hydrophobic
CHEMBL3736368 M270 7.35x34 TM7 Van der Waals
CHEMBL3736368 M270 7.35x34 TM7 hydrophobic
CHEMBL3736368 Y271 7.36x35 TM7 Van der Waals
CHEMBL3736368 I274 7.39x38 TM7 Van der Waals
CHEMBL3736368 I274 7.39x38 TM7 hydrophobic

Ligands

CHEMBL3736368

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274