Structure information

GPR6

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8TF5

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

A

REFERENCE

10.1126/SCISIGNAL.ADO8741

PUBLICATION DATE

Dec. 4, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
oleic acid A228 5.41x41 TM5 hydrophobic
oleic acid A232 5.45x45 TM5 hydrophobic
oleic acid F235 5.48x48 TM5 hydrophobic
oleic acid M236 5.49x49 TM5 hydrophobic
oleic acid V300 6.56x56 TM6 hydrophobic

Ligands

oleic acid

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Residue Diagrams

A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7
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ICL1 P A L R ICL1ECL1 L V P ECL1ICL2 A L T Y Y ICL2ECL2 W N C L A E R A A C S V V R P L ECL2ICL3 L Q Q H C ICL3ECL3 S H E D P ECL3N-term M N A S A A S L N D S Q V V V V A A E G A A A A A T A A G G P D T G E W G P P A A A A L G A G G G A N G S L E L S S Q L S A G P P G L L L P N-termC-term G C F Q S K V P F R S R S P S E V C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR6
TM5
5x41 5.41x41 A228
5x45 5.45x45 A232
5x48 5.48x48 F235
5x49 5.49x49 M236
TM6
6x56 6.56x56 V300