Structure information

CCR8

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8TLM

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

C

REFERENCE

10.1038/S41467-023-43601-8

PUBLICATION DATE

Dec. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
mAb1 Fab fragment (chain A) Q98 23.49x49 ECL1 polar (hydrogen bond)
mAb1 Fab fragment (chain A) T103 3.22x22 TM3 polar (hydrogen bond)
mAb1 Fab fragment (chain A) T103 3.22x22 TM3 Van der Waals
mAb1 Fab fragment (chain A) Q173 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) Q173 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) V174 ECL2 Van der Waals
mAb1 Fab fragment (chain A) V174 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) A175 ECL2 Van der Waals
mAb1 Fab fragment (chain A) S176 ECL2 Van der Waals
mAb1 Fab fragment (chain A) S176 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) S176 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) E177 ECL2 polar (charge-assisted hydrogen bond)
mAb1 Fab fragment (chain A) D178 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) D178 ECL2 polar (charge-assisted hydrogen bond)
mAb1 Fab fragment (chain A) G179 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) G179 ECL2 Van der Waals
mAb1 Fab fragment (chain A) L181 ECL2 hydrophobic
mAb1 Fab fragment (chain A) L181 ECL2 Van der Waals
mAb1 Fab fragment (chain A) Y187 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) Y187 ECL2 Van der Waals
mAb1 Fab fragment (chain B) N188 ECL2 Van der Waals
mAb1 Fab fragment (chain B) Q189 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain B) Q189 ECL2 Van der Waals
mAb1 Fab fragment (chain B) Q190 ECL2 Van der Waals

Ligands

mAb1 Fab fragment (chain A)

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mAb1 Fab fragment (chain B)

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Residue Diagrams

S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7
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ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR8
ECL1
23x49 23.49x49 Q98
TM3
3x22 3.22x22 T103