Structure information

GPR3

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U8F

SPECIES

Homo sapiens

RESOLUTION

3.490

PREFERRED CHAIN

R

REFERENCE

10.1021/ACS.BIOCHEM.3C00647

PUBLICATION DATE

March 6, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
palmitic acid T121 3.37x37 TM3 polar (hydrogen bond with backbone)
palmitic acid T121 3.37x37 TM3 polar (hydrogen bond)
palmitic acid I124 3.40x40 TM3 Van der Waals
palmitic acid I124 3.40x40 TM3 hydrophobic
palmitic acid G125 3.41x41 TM3 polar (hydrogen bond with backbone)
palmitic acid G125 3.41x41 TM3 Van der Waals
palmitic acid V187 ECL2 Van der Waals
palmitic acid V187 ECL2 hydrophobic
palmitic acid L190 ECL2 Van der Waals
palmitic acid L190 ECL2 hydrophobic
palmitic acid L195 5.40x40 TM5 Van der Waals
palmitic acid L198 5.43x43 TM5 polar (hydrogen bond with backbone)
palmitic acid L198 5.43x43 TM5 Van der Waals
palmitic acid A201 5.46x46 TM5 Van der Waals
palmitic acid A201 5.46x46 TM5 polar (hydrogen bond with backbone)
palmitic acid F202 5.47x47 TM5 polar (hydrogen bond with backbone)
palmitic acid F202 5.47x47 TM5 Van der Waals
palmitic acid V205 5.50x50 TM5 Van der Waals
palmitic acid V205 5.50x50 TM5 hydrophobic
palmitic acid W260 6.48x48 TM6 Van der Waals
palmitic acid F263 6.51x51 TM6 Van der Waals
palmitic acid F263 6.51x51 TM6 hydrophobic

Ligands

palmitic acid

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Residue Diagrams

A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7
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ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR3
TM3
3x37 3.37x37 T121
3x40 3.40x40 I124
3x41 3.41x41 G125
TM5
5x40 5.40x40 L195
5x43 5.43x43 L198
5x46 5.46x46 A201
5x47 5.47x47 F202
5x50 5.50x50 V205
TM6
6x48 6.48x48 W260
6x51 6.51x51 F263