Structure information

TA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WC5

SPECIES

Mus musculus

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2023.10.014

PUBLICATION DATE

Dec. 27, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Tetramethylammonium D102 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Tetramethylammonium S106 3.36x36 TM3 Van der Waals
Tetramethylammonium W261 6.48x48 TM6 hydrophobic
Tetramethylammonium F264 6.51x51 TM6 hydrophobic
Tetramethylammonium F264 6.51x51 TM6 Van der Waals
Tetramethylammonium Y287 7.39x38 TM7 hydrophobic
Tetramethylammonium Y287 7.39x38 TM7 Van der Waals
Tetramethylammonium Y291 7.43x42 TM7 hydrophobic
Tetramethylammonium Y291 7.43x42 TM7 Van der Waals

Ligands

Tetramethylammonium

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Residue Diagrams

L N G V L T A L I I L S M L S Y L S A Q 1 H S M A I V D F L L G L C I M P C S M V R 2 F A L H F I S A S S L M I D T S T H V K 3 I L V M I L V S W S L P A V Y A F G M I 4 Y V F L M V S G P I Y F S T M F A L V G S 5 G I M V G V F L V C W C P F F L C T V L 6 M P N L A S N L Y G F W Y L A D N L S 7
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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K I ICL2ECL2 L N L K G V E E L Y R S Q V S D L G G C S P F F ECL2ICL3 L E G K S Q ICL3ECL3 Y V I ECL3N-term M H L C H A I T N I S H R N S D W S R E N-termC-term G K I F Q K D S S R S K L F L C-term V Q A S L Y S L M S L I I L A T L V G N L I V I I S I S H F T P T N W L L H S M A I V D F L L G C L I M P C S M V R T V E R G E I L C K V H T S T D I M L S S A S I F H L A F I S I D R Y C A V C D N I S T I L V M I L V S W S L P A V Y A F G M I F L E S K V S G V L A F M T S F Y I P G S V M L F V Y Y R I Y F I A K G Q A R S I N R T N V Q V G A P Q S K E T K A A K T L G I M V G V F L V C W C P F F L C T V L D P F L G P P S L N D A L Y W F G Y L N S A L N P M V Y A F F Y P W L K M F R R A V L L
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Residue Table


GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D102
3x36 3.36x36 S106
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
TM7
7x38 7.39x38 Y287
7x42 7.43x42 Y291