Structure information

FZD4

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

8WM9

SPECIES

Homo sapiens

RESOLUTION

3.530

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-024-52174-Z

PUBLICATION DATE

Sept. 11, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Dishevelled-2 DEP domain K334 ICL2 polar (hydrogen bond with backbone)
Dishevelled-2 DEP domain K334 ICL2 Van der Waals
Dishevelled-2 DEP domain W335 ICL2 Van der Waals
Dishevelled-2 DEP domain W335 ICL2 polar (hydrogen bond with backbone)
Dishevelled-2 DEP domain A339 4.37x37 TM4 Van der Waals
Dishevelled-2 DEP domain I416 5.72x72 TM5 hydrophobic
Dishevelled-2 DEP domain I416 5.72x72 TM5 Van der Waals
Dishevelled-2 DEP domain L420 5.76x76 TM5 Van der Waals
Dishevelled-2 DEP domain L420 5.76x76 TM5 hydrophobic
Dishevelled-2 DEP domain K429 6.25x25 TM6 Van der Waals

Ligands

Dishevelled-2 DEP domain

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Residue Diagrams

A T S I F C L S A W V A M W I D T F E K 1 I F L S M C Y N I Y S I A Y I V R L T V 2 I V W W I S S A M G F F Y M L L F I I A 3 S S Y F H I A A W A I P A V K T I V I L 4 I F L T G I V L Y T F L P A V V F G T L A 5 G V F S V L Y T V P A T C V I A C Y F Y 6 M G S T I G V L L S M F I K L M E V A M 7
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ICL1 S S R F S ICL1ECL1 R E R I S C D F E E A A E P V L I Q E G L K ECL1ICL2 L K W ICL2ECL2 L V D A D E L T G L C Y V G N Q ECL2ICL3 Q K D G T K T D K L ICL3ECL3 W A L F R Y S A D D S ECL3N-term M A W R G A G P S V P G A P G G V G L S L G L L L Q L L L L L G P A R G F G D E E E R R C D P I R I S M C Q N L G Y N V T K M P N L V G H E L Q T D A E L Q L T T F T P L I Q Y G C S S Q L Q F F L C S V Y V P M C T E K I N I P I G P C G G M C L S V K R R C E P V L K E F G F A W P E S L N C S K F P P Q N D H N H M C M E G P G D E E V P L P H K T P I Q P G E E C H S V G T N S D Q Y I W V K R S L N C V L K C G Y D A G L Y N-termC-term N S G K V K R E K R G N G W V K P G K G S E T V V C-term S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G N T G C A I I F L L M Y F F G M A S S I W W V I L T L T W F L A A G G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N L E R L M V K I G V F S V L Y T V P A T C V I A C Y F Y E I S N N M A V E M L K I F M S L L V G I T S G M W I W S A K W Q K L V T L H T C S N R
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Residue Table


GPCRdb(A)
GPCRdb(F)
FZD4
TM4
4x37 4.37x37 A339
TM5
5x68 5.72x72 I416
5x72 5.76x76 L420