Structure information

LGR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XFP

SPECIES

Homo sapiens

RESOLUTION

3.210

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 4, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
R-spondin-2 M66 N-term polar (hydrogen bond)
R-spondin-2 A89 N-term Van der Waals
R-spondin-2 G90 N-term Van der Waals
R-spondin-2 Q113 N-term polar (hydrogen bond)
R-spondin-2 Q113 N-term Van der Waals
R-spondin-2 N114 N-term polar (hydrogen bond)
R-spondin-2 D137 N-term polar (charge-assisted hydrogen bond)
R-spondin-2 A138 N-term Van der Waals
R-spondin-2 R156 N-term Van der Waals
R-spondin-2 H157 N-term aromatic (face-to-edge)
R-spondin-2 H157 N-term Van der Waals
R-spondin-2 W159 N-term hydrophobic
R-spondin-2 W159 N-term Van der Waals
R-spondin-2 D161 N-term Van der Waals
R-spondin-2 D162 N-term Van der Waals
R-spondin-2 Q180 N-term Van der Waals
R-spondin-2 A181 N-term hydrophobic
R-spondin-2 A181 N-term Van der Waals
R-spondin-2 L186 N-term hydrophobic
R-spondin-2 L186 N-term Van der Waals
R-spondin-2 V204 N-term Van der Waals
R-spondin-2 V204 N-term hydrophobic
R-spondin-2 V205 N-term hydrophobic
R-spondin-2 V205 N-term Van der Waals
R-spondin-2 H207 N-term polar (hydrogen bond)
R-spondin-2 H207 N-term Van der Waals
R-spondin-2 H209 N-term Van der Waals
R-spondin-2 N210 N-term Van der Waals
R-spondin-2 N210 N-term polar (hydrogen bond)
R-spondin-2 N226 N-term polar (hydrogen bond)
R-spondin-2 E252 N-term polar (charge-assisted hydrogen bond)
Zinc ring finger 3 R392 N-term polar (charge-assisted hydrogen bond)
Zinc ring finger 3 T416 N-term Van der Waals
Zinc ring finger 3 G435 N-term Van der Waals
Zinc ring finger 3 N437 N-term polar (hydrogen bond)
Zinc ring finger 3 R460 N-term polar (charge-assisted hydrogen bond)
Zinc ring finger 3 Q517 N-term Van der Waals
Zinc ring finger 3 Q517 N-term polar (hydrogen bond with backbone)
Zinc ring finger 3 I518 N-term hydrophobic
Zinc ring finger 3 I519 N-term hydrophobic
Zinc ring finger 3 I519 N-term Van der Waals
Zinc ring finger 3 S538 1.32x32 TM1 Van der Waals
Zinc ring finger 3 M540 1.34x34 TM1 Van der Waals
Zinc ring finger 3 M540 1.34x34 TM1 hydrophobic
Zinc ring finger 3 I541 1.35x35 TM1 Van der Waals
Zinc ring finger 3 F547 1.41x41 TM1 hydrophobic
Zinc ring finger 3 F547 1.41x41 TM1 Van der Waals
Zinc ring finger 3 I548 1.42x42 TM1 hydrophobic
Zinc ring finger 3 I548 1.42x42 TM1 Van der Waals
Zinc ring finger 3 I781 7.33x32 TM7 hydrophobic
Zinc ring finger 3 I788 7.40x39 TM7 Van der Waals
Zinc ring finger 3 F803 7.55x55 TM7 hydrophobic
Zinc ring finger 3 F803 7.55x55 TM7 Van der Waals

Ligands

R-spondin-2

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Zinc ring finger 3

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Residue Diagrams

L N F F L A V L F I F W V T L R I M W S 1 G L I S V S N L F M G I Y T G I L T F L 2 L M L L F I A S E S S F V A L F G A V K 3 F R V A A L L A F L G A T V A G C F P L 4 Y I V A M L L F A L S N L L V L T V T F 5 A W L I F T N C I F F C P V A F F S F A 6 V P N L C A P L P F F I L T V S K M I 7
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ICL1 C T S L ICL1ECL1 G R F A E F G I W W E T G ECL1ICL2 I M K N G K S N ICL2ECL2 R G E Y S A S P L C L P F P T G E T P ECL2ICL3 E D L S E ICL3ECL3 A I S I ECL3N-term M P G P L G L L C F L A L G L L G S A G P S G A A P P L C A A P C S C D G D R R V D C S G K G L T A V P E G L S A F T Q A L D I S M N N I T Q L P E D A F K N F P F L E E L Q L A G N D L S F I H P K A L S G L K E L K V L T L Q N N Q L K T V P S E A I R G L S A L Q S L R L D A N H I T S V P E D S F E G L V Q L R H L W L D D N S L T E V P V H P L S N L P T L Q A L T L A L N K I S S I P D F A F T N L S S L V V L H L H N N K I R S L S Q H C F D G L D N L E T L D L N Y N N L G E F P Q A I K A L P S L K E L G F H S N S I S V I P D G A F D G N P L L R T I H L Y D N P L S F V G N S A F H N L S D L H S L V I R G A S M V Q Q F P N L T G T V H L E S L T L T G T K I S S I P N N L C Q E Q K M L R T L D L S Y N N I R D L P S F N G C H A L E E I S L Q R N Q I Y Q I K E G T F Q G L I S L R I L D L S R N L I H E I H S R A F A T L G P I T N L D V S F N E L T S F P T E G L N G L N Q L K L V G N F K L K E A L A A K D F V N L R S L S V P Y A Y Q C C A F W G C D S Y A N L N T E D N S L Q D H S V A Q E K G T A D A A N V T S T L E N E E H S Q I I I H C T P S T G A F K P C E Y L L G N-termC-term T K K S G S V S V S I S S Q G G C L E Q D F Y Y D C G M Y S H L Q G N L T V C D C C E S F L L T K P V S C K H L I K S H S C P A L A V A S C Q R P E G Y W S D C G T Q S A H S D Y A D E E D S F V S D S S D Q V Q A C G R A C F Y Q S R G F P L V R Y A Y N L P R V K D C-term S W M I R L T V W F I F L V A L F F N L L V I L T T F A S P S S K L F I G L I S V S N L F M G I Y T G I L T F L D A V S W S G C K V A G F L A V F S S E S A I F L L M L A T V E R S L S A K D H L K Q F R V A A L L A F L G A T V A G C F P L F H S L G F T V T L V L L N S L A F L L M A V I Y T K L Y C N L E K N S Q S S M I K H V A W L I F T N C I F F C P V A F F S F A P L I T S P E I M K S V T L I F F P L P A C L N P V L Y V F F N P K W K L V F K E D L K R R
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Residue Table


GPCRdb(A)
GPCRdb(A)
LGR4
TM1
1x32 1.32x32 S538
1x34 1.34x34 M540
1x35 1.35x35 I541
1x41 1.41x41 F547
1x42 1.42x42 I548
TM7
7x32 7.33x32 I781
7x39 7.40x39 I788
7x55 7.55x55 F803