Structure information

oxoglutarate receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8YYW

SPECIES

Homo sapiens

RESOLUTION

3.160

PREFERRED CHAIN

E

REFERENCE

10.1038/S41467-025-67101-Z

PUBLICATION DATE

April 9, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
α-ketoglutaric acid R110 3.29x29 TM3 polar (charge-assisted hydrogen bond)
α-ketoglutaric acid F113 3.32x32 TM3 hydrophobic
α-ketoglutaric acid F113 3.32x32 TM3 Van der Waals
α-ketoglutaric acid H114 3.33x33 TM3 polar (hydrogen bond)
α-ketoglutaric acid H114 3.33x33 TM3 Van der Waals
α-ketoglutaric acid D185 45.52x52 ECL2 Van der Waals
α-ketoglutaric acid L186 ECL2 Van der Waals
α-ketoglutaric acid T187 ECL2 Van der Waals
α-ketoglutaric acid R261 6.55x55 TM6 polar (charge-assisted hydrogen bond)
α-ketoglutaric acid Y284 7.35x34 TM7 polar (hydrogen bond)
α-ketoglutaric acid Y284 7.35x34 TM7 polar (hydrogen bond)
α-ketoglutaric acid R288 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

α-ketoglutaric acid

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Residue Diagrams

A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7
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ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
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Residue Table


GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM3
3x29 3.29x29 R110
3x32 3.32x32 F113
3x33 3.33x33 H114
ECL2
45x52 45.52x52 D185
TM6
6x55 6.55x55 R261
TM7
7x34 7.35x34 Y284
7x38 7.39x38 R288