Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9AS6

SPECIES

Homo sapiens

RESOLUTION

3.070

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

April 2, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
mescaline D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
mescaline V156 3.33x33 TM3 Van der Waals
mescaline V156 3.33x33 TM3 hydrophobic
mescaline S159 3.36x36 TM3 Van der Waals
mescaline L229 45.52x52 ECL2 Van der Waals
mescaline L229 45.52x52 ECL2 hydrophobic
mescaline G238 5.42x43 TM5 Van der Waals
mescaline S242 5.46x461 TM5 polar (hydrogen bond)
mescaline S242 5.46x461 TM5 Van der Waals
mescaline F339 6.51x51 TM6 Van der Waals
mescaline F339 6.51x51 TM6 aromatic (edge-to-face)
mescaline F340 6.52x52 TM6 hydrophobic
mescaline F340 6.52x52 TM6 Van der Waals
mescaline V366 7.39x38 TM7 Van der Waals
mescaline Y370 7.43x42 TM7 Van der Waals

Ligands

mescaline

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
ECL2
45x52 45.52x52 L229
TM5
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370