Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

9IVG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.APSB.2024.09.002

PUBLICATION DATE

Nov. 27, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
glucagon-like peptide 1-(9-36) S31 N-term polar (hydrogen bond)
glucagon-like peptide 1-(9-36) L32 N-term Van der Waals
glucagon-like peptide 1-(9-36) L32 N-term polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) T35 N-term polar (hydrogen bond)
glucagon-like peptide 1-(9-36) D67 N-term polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) D67 N-term Van der Waals
glucagon-like peptide 1-(9-36) E68 N-term polar (charge-assisted hydrogen bond)
glucagon-like peptide 1-(9-36) Y69 N-term Van der Waals
glucagon-like peptide 1-(9-36) Y69 N-term hydrophobic
glucagon-like peptide 1-(9-36) L89 N-term hydrophobic
glucagon-like peptide 1-(9-36) L89 N-term Van der Waals
glucagon-like peptide 1-(9-36) P90 N-term Van der Waals
glucagon-like peptide 1-(9-36) W91 N-term Van der Waals
glucagon-like peptide 1-(9-36) L118 N-term hydrophobic
glucagon-like peptide 1-(9-36) L118 N-term Van der Waals
glucagon-like peptide 1-(9-36) L141 1.36x36 TM1 polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) L141 1.36x36 TM1 Van der Waals
glucagon-like peptide 1-(9-36) L142 1.37x37 TM1 Van der Waals
glucagon-like peptide 1-(9-36) Y145 1.40x40 TM1 Van der Waals
glucagon-like peptide 1-(9-36) Y145 1.40x40 TM1 hydrophobic
glucagon-like peptide 1-(9-36) Y148 1.43x43 TM1 Van der Waals
glucagon-like peptide 1-(9-36) D198 2.68x68 TM2 Van der Waals
glucagon-like peptide 1-(9-36) L201 2.71x71 TM2 hydrophobic
glucagon-like peptide 1-(9-36) L201 2.71x71 TM2 Van der Waals
glucagon-like peptide 1-(9-36) K202 2.72x72 TM2 Van der Waals
glucagon-like peptide 1-(9-36) Y205 2.75x75 TM2 hydrophobic
glucagon-like peptide 1-(9-36) Y205 2.75x75 TM2 Van der Waals
glucagon-like peptide 1-(9-36) A208 2.78x78 TM2 Van der Waals
glucagon-like peptide 1-(9-36) A208 2.78x78 TM2 polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) Q211 ECL1 polar (hydrogen bond)
glucagon-like peptide 1-(9-36) W214 ECL1 Van der Waals
glucagon-like peptide 1-(9-36) W214 ECL1 hydrophobic

Ligands

glucagon-like peptide 1-(9-36)

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x33 1.37x37 L142
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x61 2.68x68 D198
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205